Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.79 |
| ▸ | MEN1 | O00255 | 2/20 | 0.79 |
| ▸ | GAA | P10253 | 2/20 | 0.66 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.61 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.55 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.55 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.54 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8242118 | 0.85 | MEN1 (0.57) | KMT2AMEN1GAALIMK2TMEM97 | |
| SCHEMBL13229125 | 0.84 | KMT2A (0.90) | KMT2AMEN1GAAHPGDALDH1A1 | |
| SCHEMBL18773963 | 0.84 | MEN1 (0.60) | KMT2AMEN1GAALIMK2TP53 | |
| SCHEMBL15676742 | 0.84 | MEN1 (0.60) | KMT2AMEN1GAALIMK2TP53 | |
| SCHEMBL1003665 | 0.84 | KMT2A (0.83) | KMT2AMEN1GAALIMK2HPGD | |
| SCHEMBL18186542 | 0.83 | KMT2A (0.82) | KMT2AMEN1GAAHPGDALDH1A1 | |
| SCHEMBL2228587 | 0.83 | KMT2A (0.82) | KMT2AMEN1GAALIMK2HPGD | |
| SCHEMBL15676710 | 0.83 | KMT2A (0.82) | KMT2AMEN1GAAHPGDALDH1A1 | |
| SCHEMBL1196932 | 0.83 | MEN1 (0.58) | KMT2AMEN1GAALIMK2TP53 | |
| SCHEMBL5643137 | 0.83 | HDAC1 (0.66) | KMT2AMEN1LIMK2ALDH1A1HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7241759-B2 | Benzo[1,2,5]thiadiazole compounds | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-07-10 | — | — | US | disclosed |