Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.56 |
| ▸ | HSD17B2 | P37059 | 6/20 | 0.55 |
| ▸ | HSD17B1 | P14061 | 5/20 | 0.55 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | LIMK2 | P53671 | 2/20 | 0.49 |
| ▸ | GRM5 | P41594 | 1/20 | 0.48 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.47 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.47 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.47 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | GPR17 | Q13304 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18773897 | 0.90 | KMT2A (0.69) | MEN1KMT2AHSP90AA1HSD17B2HSD17B1 | |
| SCHEMBL15676742 | 0.86 | MEN1 (0.60) | MEN1KMT2AHSP90AA1HSD17B2HSD17B1 | |
| SCHEMBL2228587 | 0.85 | KMT2A (0.82) | MEN1KMT2AHSD17B2HSD17B1GAA | |
| SCHEMBL1196932 | 0.85 | MEN1 (0.58) | MEN1KMT2AHSP90AA1HSD17B2HSD17B1 | |
| SCHEMBL5593762 | 0.84 | RIPK1 (0.50) | MEN1KMT2AHSP90AA1HSD17B2HSD17B1 | |
| SCHEMBL5644480 | 0.84 | KMT2A (0.79) | MEN1KMT2AHSP90AA1HSD17B2HSD17B1 | |
| SCHEMBL10268038 | 0.84 | MEN1 (0.57) | MEN1KMT2AHSD17B2HSD17B1RIPK1 | |
| SCHEMBL1690715 | 0.83 | RIPK1 (0.57) | MEN1KMT2AHSD17B2HSD17B1RIPK1 | |
| SCHEMBL18773850 | 0.82 | KMT2A (0.67) | MEN1KMT2AHSP90AA1HSD17B2HSD17B1 | |
| SCHEMBL10323268 | 0.82 | MEN1 (0.51) | MEN1KMT2AHSP90AA1HSD17B2HSD17B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773786-B1 | FIVE-MEMBERED HETEROCYCLES USEFUL AS SERINE PROTEASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2017-04-26 | — | — | EP | disclosed |