Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NSD2 | O96028 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.66 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.66 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.66 |
| ▸ | MEN1 | O00255 | 3/20 | 0.66 |
| ▸ | LIMK2 | P53671 | 2/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | MLYCD | O95822 | 1/20 | 0.57 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.56 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.53 |
| ▸ | MAOA | P21397 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5644792 | 0.93 | LIMK2 (0.70) | NSD2KMT2AHDAC1HDAC6MEN1 | |
| SCHEMBL1003665 | 0.88 | KMT2A (0.83) | KMT2AHDAC1HDAC6MEN1LIMK2 | |
| SCHEMBL30131237 | 0.84 | NSD2 (0.68) | NSD2KMT2AHDAC1HDAC6LIMK2 | |
| SCHEMBL5646698 | 0.84 | NSD2 (0.68) | NSD2KMT2AHDAC1HDAC6MEN1 | |
| SCHEMBL13184565 | 0.84 | MCHR1 (0.68) | NSD2KMT2AHDAC1HDAC6LIMK2 | |
| SCHEMBL5643137 | 0.83 | HDAC1 (0.66) | KMT2AHDAC1HDAC6MEN1LIMK2 | |
| SCHEMBL18773928 | 0.83 | KMT2A (0.62) | NSD2KMT2AHDAC1HDAC6MEN1 | |
| SCHEMBL15676756 | 0.82 | KMT2A (0.65) | NSD2KMT2AHDAC1HDAC6MEN1 | |
| SCHEMBL5643054 | 0.81 | KMT2A (0.68) | NSD2KMT2AHDAC1HDAC6MEN1 | |
| SCHEMBL2164868 | 0.81 | NSD2 (0.64) | NSD2KMT2AHDAC1HDAC6MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7241759-B2 | Benzo[1,2,5]thiadiazole compounds | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-07-10 | — | — | US | disclosed |