Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G4B | P0C869 | 2/20 | 0.46 |
| ▸ | PTPN11 | Q06124 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 4/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6562548 | 0.94 | PLA2G4B (0.47) | PLA2G4BPTPN11LMNAGAAMAPK10 | |
| SCHEMBL6341883 | 0.92 | PLA2G4B (0.46) | PLA2G4BPTPN11LMNAGAAMAPK10 | |
| SCHEMBL6331891 | 0.92 | PLA2G4B (0.46) | PLA2G4BPTPN11LMNAGAAMAPK10 | |
| SCHEMBL8383224 | 0.91 | PLA2G4B (0.42) | PLA2G4BPTPN11LMNAGAAMAPK10 | |
| SCHEMBL8517433 | 0.91 | PLA2G4B (0.42) | PLA2G4BPTPN11LMNAGAAMAPK10 | |
| SCHEMBL6562240 | 0.91 | PLA2G4B (0.51) | PLA2G4BPTPN11GAACNR2USP2 | |
| SCHEMBL7522311 | 0.91 | PLA2G4B (0.51) | PLA2G4BPTPN11GAACNR2USP2 | |
| SCHEMBL6334661 | 0.89 | PLA2G4B (0.41) | PLA2G4BPTPN11LMNAGAAMAPK10 | |
| SCHEMBL14112068 | 0.88 | PLA2G4B (0.40) | PLA2G4BPTPN11LMNAGAAMAPK10 | |
| SCHEMBL13593752 | 0.88 | PLA2G4B (0.48) | PLA2G4BPTPN11GAACNR2USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7166659-B2 | Substituted 5-aryl-2-(2-hydroxyphenyl)-2H-benzotriazole UV absorbers, compositions stabilized therewith and process for preparation thereof | CIBA SPECIALTY CHEMICALS CORPORATION (US) | 2007-01-23 | — | — | US | disclosed |
| US-7148274-B2 | Substituted 5-aryl-2-(2-hydroxyphenyl)-2h-benzotriazole UV absorbers, compositions stabilized therewith and process for preparation thereof | CIBA SPECIALTY CHEMICALS CORPORATION (US) | 2006-12-12 | — | — | US | disclosed |
| EP-1337520-B1 | SUBSTITUTED 5-ARYL AND 5-HETEROARYL-2-(2-HYDROXYPHENYL)-2H-BENZOTRIAZOLE DERIVATIVES AS UV ABSORBERS | CIBA SC HOLDING AG (CH) | 2004-12-15 | — | — | EP | disclosed |
| US-6800676-B2 | ULTRAVIOLET RADIATION ABSORBERS; HEAT AND OXIDATION RESISTANCE | CIBA SPECIALTY CHEMICALS CORPORATION | 2004-10-05 | — | — | US | disclosed |
| US-20040192927-A1 | Substituted 5-aryl-2-(2-hydroxyphenyl)-2H-benzotriazole UV absorbers, compositions stabilized therewith and process for preparation thereof | PASTOR STEPHEN D (US) | 2004-09-30 | — | — | US | disclosed |
| US-20040157966-A1 | Substituted 5-aryl-2-(2-hydroxyphenyl)-2h-benzotriazole UV absorbers, compositions stabilized therewith and process for preparation thereof | PASTOR STEPHEN D (US) | 2004-08-12 | — | — | US | disclosed |
| US-6774238-B2 | REACTING 5-SUBSTITUTED BENZOTRIAZOLE WITH ARYLBORONIC ACID IN PRESENCE OF PALLADIUM CATALYST; DEHALOGENATION; ARYLATION | CIBA SPECIALTY CHEMICALS CORPORATION | 2004-08-10 | — | — | US | disclosed |
| US-20040092628-A1 | Substituted 5-aryl-2-(2-hydroxyphenyl)-2h-benzotriazole UV absorbers, compositions stabilized therewith and process for preparatiion thereof | PASTOR STEPHEN D (US) | 2004-05-13 | — | — | US | disclosed |
| US-6649770-B1 | Exhibit superior hydrolytic stability, handling and storage stability as well as good resistance to extractability when present in stabilized composition | CIBA SPECIALTY CHEMICALS CORPORATION | 2003-11-18 | — | — | US | disclosed |
| EP-1337520-A1 | SUBSTITUTED 5-ARYL AND 5-HETEROARYL-2-(2-HYDROXYPHENYL)-2H-BENZOTRIAZOLE DERIVATIVES AS UV ABSORBERS | Ciba SC Holding AG (CH) | 2003-08-27 | — | — | EP | disclosed |
| EP-1305297-A1 | BENZOTRIAZOLES CONTAINING ALPHA-CUMYL GROUPS SUBSTITUTED BY HETEROATOMS AND COMPOSITIONS STABILIZED THEREWITH | Ciba SC Holding AG (CH) | 2003-05-02 | — | — | EP | disclosed |
| US-20030004235-A1 | Benzotriazoles containing phenyl groups substituted by heteroatoms and compositions stabilized therewith | CIBA SPECIALTY CHEMICALS CORP. | 2003-01-02 | — | — | US | disclosed |
| US-6489383-B1 | SUCH AS 2-(2-HYDROXY-3-(1,1-DI(4-2-(BROMOETHOXY)PHENYL) ETHYL)-5-TERT-BUTYLPHENYL)-2H-BENZOTRIAZOLE FOR USE AS STOVING LACQUER, FINISHING ENAMEL FOR AUTOMOBILES | CIBA SPECIALTY CHEMICALS CORPORATION | 2002-12-03 | — | — | US | disclosed |
| US-20020169239-A1 | 2H-benzotriazole UV absorbers substituted with 1,1-diphenylakyl groups and compositions stabilized therewith | WOOD MERVIN G (US) | 2002-11-14 | — | — | US | disclosed |
| WO-2002042281-A1 | SUBSTITUTED 5-ARYL AND 5-HETEROARYL-2-(2-HYDROXYPHENYL)-2H-BENZOTRIAZOLE DERIVATIVES AS UV ABSORBERS | CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) | 2002-05-30 | — | — | WO | disclosed |
| US-6392056-B1 | FOR THERMOPLASTIC RESINS | CIBA SPECIALTY CHEMICAL CORPORATION | 2002-05-21 | — | — | US | disclosed |
| US-6387992-B1 | HEAT, OXIDATION AND LIGHT RESISTANCE | CIBA SPECIALTY CHEMICALS CORPORATION | 2002-05-14 | — | — | US | disclosed |
| WO-2002012205-A1 | BENZOTRIAZOLES CONTAINING α-CUMYL GROUPS SUBSTITUTED BY HETEROATOMS AND COMPOSITIONS STABILIZED THEREWITH | CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) | 2002-02-14 | — | — | WO | disclosed |
| WO-2002012204-A1 | 2H-BENZOTRIAZOLE UV ABSORBERS SUBSTITUTED WITH 1,1-DIPHENYLALKYL GROUPS AND COMPOSITIONS STABILIZED THEREWITH | CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) | 2002-02-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040192927-A1 | Substituted 5-aryl-2-(2-hydroxyphenyl)-2H-benzotriazole UV absorbers, compositions stabilized therewith and process for preparation thereof | EBPL, DDT, AHR | PLA2G4B 2971/4885PTPN11 3160/4885LMNA 1566/4885 |
| US-20020169239-A1 | 2H-benzotriazole UV absorbers substituted with 1,1-diphenylakyl groups and compositions stabilized therewith | SUV39H1, SUV39H2, PAH | PLA2G4B 3138/4885PTPN11 3864/4885LMNA 3381/4885 |
| US-20040092628-A1 | Substituted 5-aryl-2-(2-hydroxyphenyl)-2h-benzotriazole UV absorbers, compositions stabilized therewith and process for preparatiion thereof | AHR, PAH, CCNL2 | PLA2G4B 2837/4885PTPN11 3584/4885LMNA 502/4885 |
| US-20030004235-A1 | Benzotriazoles containing phenyl groups substituted by heteroatoms and compositions stabilized therewith | SUV39H1, SUV39H2, TPST2 | PLA2G4B 3665/4885PTPN11 2804/4885LMNA 2979/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.