Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.53 |
| ▸ | NPC1 | O15118 | 4/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.53 |
| ▸ | GAA | P10253 | 3/20 | 0.53 |
| ▸ | PHGDH | O43175 | 1/20 | 0.52 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.50 |
| ▸ | ABCC1 | P33527 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | PDE5A | O76074 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31711679 | 0.88 | POLB (0.69) | POLBSMN1; SMN2NPC1RAB9AMAPK1 | |
| SCHEMBL5652196 | 0.83 | POLB (0.78) | POLBSMN1; SMN2NPC1RAB9AMAPK1 | |
| SCHEMBL5649484 | 0.79 | HDAC1 (0.58) | NPC1RAB9AMAPK1ABCB1KMT2A | |
| SCHEMBL6541728 | 0.76 | SMN1; SMN2 (0.72) | POLBSMN1; SMN2NPC1RAB9AMAPK1 | |
| SCHEMBL8293254 | 0.75 | MAPT (0.59) | SMN1; SMN2NPC1RAB9AMAPK1GAA | |
| SCHEMBL2414416 | 0.75 | PHGDH (0.70) | POLBSMN1; SMN2NPC1RAB9AMAPK1 | |
| SCHEMBL20984593 | 0.73 | ALDH1A1 (0.47) | POLBSMN1; SMN2MAPK1GAAALDH1A1 | |
| SCHEMBL9332891 | 0.72 | MAPT (0.67) | POLBSMN1; SMN2MAPK1ALDH1A1MAPT | |
| Oxalic Acid SCHEMBL20984591 | 0.72 | TSHR (0.44) | POLBSMN1; SMN2MAPK1ALDH1A1MAPT | |
| Phosphoric Acid SCHEMBL20984988 | 0.72 | KMT2A (0.44) | POLBSMN1; SMN2NPC1RAB9AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7183415-B2 | Quinoline compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-02-27 | — | — | US | disclosed |
| US-7183415-B2 | Quinoline compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-02-27 | — | — | US | disclosed |
| US-7183415-B2 | Quinoline compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-02-27 | — | — | US | disclosed |
| US-20050209213-A1 | Quinoline compound | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2005-09-22 | — | — | US | disclosed |
| EP-1447402-A1 | QUINOLINE COMPOUND | Takeda Chemical Industries, Ltd. (JP) | 2004-08-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050209213-A1 | Quinoline compound | MC1R, MC2R, TYR | POLB 3523/4885SMN1; SMN2 3577/4885NPC1 1091/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.