Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 5/20 | 0.46 |
| ▸ | PARP1 | P09874 | 4/20 | 0.37 |
| ▸ | PARP2 | Q9UGN5 | 4/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.36 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.36 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 5/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 5/20 | 0.36 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | F10 | P00742 | 1/20 | 0.32 |
| ▸ | RXRA | P19793 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL5648145 | 1.00 | PNMT (0.46) | PNMTPARP1PARP2KCNH2TPSAB1 | |
| SCHEMBL4760446 | 0.92 | PNMT (0.52) | PNMTPARP1PARP2KCNH2TPSAB1 | |
| SCHEMBL4760447 | 0.92 | PNMT (0.52) | PNMTPARP1PARP2KCNH2TPSAB1 | |
| SCHEMBL5648139 | 0.82 | PNMT (0.46) | PNMTPARP1PARP2KCNH2TPSAB1 | |
| Trifluoroacetic Acid SCHEMBL8457040 | 0.78 | PNMT (0.62) | PNMTPARP1PARP2KCNH2TPSAB1 | |
| Trifluoroacetic Acid SCHEMBL17965628 | 0.78 | PNMT (0.71) | PNMTPARP1PARP2KCNH2TPSAB1 | |
| SCHEMBL8312456 | 0.77 | PNMT (0.51) | PNMTPARP1PARP2KCNH2TPSAB1 | |
| Trifluoroacetic Acid SCHEMBL17965645 | 0.75 | PNMT (0.49) | PNMTPARP1PARP2KCNH2TPSAB1 | |
| Trifluoroacetic Acid SCHEMBL31078582 | 0.75 | PNMT (0.81) | PNMTPARP1PARP2KCNH2TPSAB1 | |
| SCHEMBL2559315 | 0.72 | PNMT (0.56) | PNMTPARP1PARP2KCNH2TPSAB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7265128-B2 | 3-amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes | MERCK & CO., INC. (US) | 2007-09-04 | — | — | US | disclosed |
| US-20060069116-A1 | 3-Amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes | MERCK SHARP & DOHME LLC | 2006-03-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060069116-A1 | 3-Amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes | DPP4, DPP3, DPP7 | PNMT 1801/4885PARP1 2478/4885PARP2 2191/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.