Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | ENPEP | Q07075 | 4/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | PTGIR | P43119 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2942452 | 0.88 | CNR1 (0.37) | KMT2AATMCNR1CNR2ENPEP | |
| SCHEMBL2942451 | 0.88 | CNR1 (0.37) | KMT2AATMCNR1CNR2ENPEP | |
| SCHEMBL5648479 | 0.87 | CNR1 (0.36) | KMT2AATMCNR1CNR2ENPEP | |
| SCHEMBL5741003 | 0.76 | CNR1 (0.39) | KMT2ACNR1CNR2 | |
| SCHEMBL5741002 | 0.76 | CNR1 (0.39) | KMT2ACNR1CNR2 | |
| SCHEMBL2944289 | 0.75 | CNR1 (0.41) | CNR1CNR2ENPEPSRC | |
| SCHEMBL27538428 | 0.75 | CNR1 (0.41) | CNR1CNR2ENPEPSRC | |
| SCHEMBL6616817 | 0.69 | NAALAD2 (0.45) | KMT2AATMCNR1CNR2 | |
| SCHEMBL6616814 | 0.69 | NAALAD2 (0.45) | KMT2AATMCNR1CNR2 | |
| SCHEMBL5840814 | 0.68 | PTGS1 (0.44) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1427718-B1 | BENZOTHIEPINE ILEAL BILE ACID TRANSPORT INHIBOTORS | ASTRAZENECA AB (SE) | 2006-11-15 | — | — | EP | claimed |
| US-7226943-B2 | Benzothiepine ileal bile acid transport inhibitors | ASTRAZENECA AB (SE) | 2007-06-05 | — | — | US | disclosed |
| EP-1427718-B1 | BENZOTHIEPINE ILEAL BILE ACID TRANSPORT INHIBOTORS | ASTRAZENECA AB (SE) | 2006-11-15 | — | — | EP | disclosed |
| US-20050043393-A1 | Benzothiepine ileal bile acid transport inhibitors | ASTRAZENECA AB | 2005-02-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050043393-A1 | Benzothiepine ileal bile acid transport inhibitors | SLC10A2, SLC10A1, ABCB11 | KMT2A 2859/4885ATM 4485/4885CNR1 2704/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.