Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 11/20 | 0.32 |
| ▸ | DPP8 | Q6V1X1 | 5/20 | 0.32 |
| ▸ | DPP7 | Q9UHL4 | 8/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.31 |
| ▸ | ACE | P12821 | 1/20 | 0.31 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5648959 | 0.83 | KLK5 (0.32) | KLK5DPP4DPP8DPP7SCN9A | |
| SCHEMBL5651226 | 0.81 | DPP4 (0.41) | KLK5DPP4DPP8DPP7SCN9A | |
| SCHEMBL5665480 | 0.72 | DPP4 (0.40) | KLK5DPP4DPP7SCN9AACE | |
| SCHEMBL5231868 | 0.72 | DPP4 (0.40) | KLK5DPP4DPP7SCN9AACE | |
| SCHEMBL1509260 | 0.67 | DPP4 (0.67) | DPP4DPP8DPP7DPP9 | |
| SCHEMBL1519632 | 0.65 | PIN1 (0.55) | KLK5ACEATM | |
| SCHEMBL738631 | 0.65 | PIN1 (0.55) | KLK5ACEATM | |
| SCHEMBL738632 | 0.65 | PIN1 (0.55) | KLK5ACEATM | |
| SCHEMBL5487719 | 0.65 | DPP4 (0.53) | DPP4DPP8DPP7DPP9 | |
| SCHEMBL7919249 | 0.63 | DPP4 (0.58) | DPP4DPP8DPP7ACEDPP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7307164-B2 | β-amino heterocyclic dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes | MERCK & CO., INC. (US) | 2007-12-11 | — | — | US | disclosed |