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Sugi Predict / Compounds / SCHEMBL564897

SCHEMBL564897

SCHEMBL564897

CC(C)CN(Cc1cc(Cl)c2c(c1)OCCCO2)C(=O)C1CN(Cc2cccc3[nH]ccc23)CCO1

nearest known ligand 0.78

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PROKR2 Q8NFJ6 5/20 0.78
▸ KDM4E B2RXH2 1/20 0.35
▸ ALDH1A1 P00352 1/20 0.35
▸ HPGD P15428 1/20 0.35
▸ SMN1; SMN2 Q16637 1/20 0.35
▸ HSD17B10 Q99714 1/20 0.35
▸ PKM P14618 2/20 0.34
▸ MAP3K7 O43318 2/20 0.33
▸ TAB1 Q15750 2/20 0.33
▸ PDE2A O00408 1/20 0.33
▸ GRN P28799 1/20 0.32
▸ SORT1 Q99523 1/20 0.32
▸ DRD4 P21917 1/20 0.32
▸ CCR3 P51677 1/20 0.32
▸ OPRM1 P35372 2/20 0.32
▸ OPRK1 P41145 2/20 0.32
▸ OPRL1 P41146 1/20 0.32
▸ TACR1 P25103 2/20 0.32
▸ GAA P10253 1/20 0.31
▸ MAPT P10636 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL564948 0.91 PROKR2 (0.65) PROKR2KDM4EALDH1A1HPGDSMN1; SMN2
SCHEMBL565726 0.90 PROKR2 (0.78) PROKR2KDM4EPKMPDE2ACCR3
SCHEMBL565832 0.90 PROKR2 (0.78) PROKR2KDM4EALDH1A1PDE2AMAPT
SCHEMBL10107300 0.90 PROKR2 (0.78) PROKR2KDM4EALDH1A1PDE2AMAPT
SCHEMBL565575 0.89 PROKR2 (0.74) PROKR2KDM4EALDH1A1HPGDSMN1; SMN2
SCHEMBL565706 0.87 PROKR2 (0.75) PROKR2KDM4EALDH1A1HPGDSMN1; SMN2
SCHEMBL564199 0.87 PROKR2 (0.74) PROKR2KDM4EALDH1A1HPGDSMN1; SMN2
SCHEMBL565197 0.86 PROKR2 (0.70) PROKR2KDM4EALDH1A1HPGDSMN1; SMN2
SCHEMBL20936053 0.86 PROKR2 (0.77) PROKR2KDM4EALDH1A1PKMDRD4
SCHEMBL565611 0.86 PROKR2 (0.73) PROKR2KDM4EALDH1A1HPGDSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8722896-B2 Prokineticin receptor antagonists and uses thereof THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2014-05-13 — — US disclosed
US-8722896-B2 Prokineticin receptor antagonists and uses thereof THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2014-05-13 — — US disclosed
US-8722896-B2 Prokineticin receptor antagonists and uses thereof THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2014-05-13 — — US disclosed
US-20120035149-A1 Prokineticin Receptor Antagonists And Uses Thereof THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2012-02-09 — — US disclosed
US-20120035149-A1 Prokineticin Receptor Antagonists And Uses Thereof THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2012-02-09 — — US disclosed
US-20120035149-A1 Prokineticin Receptor Antagonists And Uses Thereof THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2012-02-09 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120035149-A1 Prokineticin Receptor Antagonists And Uses Thereof PROKR2, PROKR1, GIPR PROKR2 1/4885KDM4E 4874/4885ALDH1A1 4725/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.