Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.42 |
| ▸ | HTR1D | P28221 | 6/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 7/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 6/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 6/20 | 0.40 |
| ▸ | HTR1B | P28222 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | RAD52 | P43351 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL108044 | 0.84 | — | — | |
| SCHEMBL9210434 | 0.75 | RAD52 (0.44) | TAAR1KDM4ENISCHHTR1DADRA1A | |
| Phosphoric Acid SCHEMBL2806511 | 0.72 | KDM4E (0.47) | TAAR1KDM4ENISCHHTR1DADRA1A | |
| SCHEMBL7265518 | 0.72 | TAAR1 (0.44) | TAAR1KDM4ENISCHHTR1DADRA1A | |
| SCHEMBL2632724 | 0.71 | — | — | |
| SCHEMBL20912399 | 0.70 | — | — | |
| SCHEMBL10629978 | 0.69 | FDPS (0.44) | TAAR1KDM4ENISCHADRA1AADRA1D | |
| Phosphoric Acid SCHEMBL4317328 | 0.69 | ADRA2B (0.44) | TAAR1KDM4ENISCHHTR1DADRA1A | |
| SCHEMBL20836033 | 0.68 | NISCH (0.47) | TAAR1NISCHHTR1DADRA1AADRA1D | |
| SCHEMBL14218507 | 0.68 | TAAR1 (0.44) | TAAR1NISCHHTR1DADRA1AADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7235559-B1 | Therapeutic quinazoline derivatives | ASTRAZENECA AB (SE) | 2007-06-26 | — | — | US | disclosed |
| EP-1218355-A1 | THERAPEUTIC QUINAZOLINE DERIVATIVES | AstraZeneca AB (SE) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001021597-A1 | THERAPEUTIC QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2001-03-29 | — | — | WO | disclosed |