Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 12/20 | 0.72 |
| ▸ | KDR | P35968 | 9/20 | 0.69 |
| ▸ | EGFR | P00533 | 6/20 | 0.69 |
| ▸ | AURKA | O14965 | 2/20 | 0.68 |
| ▸ | FLT4 | P35916 | 2/20 | 0.66 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.66 |
| ▸ | CIT | O14578 | 1/20 | 0.66 |
| ▸ | GAK | O14976 | 1/20 | 0.66 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.66 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.66 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.66 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.66 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.66 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.66 |
| ▸ | STK17B | O94768 | 1/20 | 0.66 |
| ▸ | STK10 | O94804 | 1/20 | 0.66 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.66 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.66 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.66 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28350823 | 0.90 | AURKA (0.71) | SRCKDREGFRAURKAFLT4 | |
| SCHEMBL28354861 | 0.90 | AURKA (0.71) | SRCKDREGFRAURKAFLT4 | |
| SCHEMBL3531151 | 0.89 | SRC (0.86) | SRCKDREGFRAURKAFLT4 | |
| SCHEMBL5652477 | 0.87 | SRC (0.78) | SRCKDREGFRAURKAFLT4 | |
| SCHEMBL5650807 | 0.86 | SRC (0.65) | SRCKDREGFRAURKAFLT4 | |
| SCHEMBL28354676 | 0.86 | SRC (0.77) | SRCKDREGFRAURKAFLT4 | |
| SCHEMBL28882352 | 0.86 | SRC (0.77) | SRCKDREGFRAURKAFLT4 | |
| SCHEMBL28350783 | 0.85 | SRC (0.73) | SRCKDREGFRAURKAFLT4 | |
| SCHEMBL28354322 | 0.85 | SRC (0.73) | SRCKDREGFRAURKAFLT4 | |
| SCHEMBL13529060 | 0.85 | SRC (0.84) | SRCKDREGFRAURKAFLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7235559-B1 | Therapeutic quinazoline derivatives | ASTRAZENECA AB (SE) | 2007-06-26 | — | — | US | disclosed |
| EP-1218355-A1 | THERAPEUTIC QUINAZOLINE DERIVATIVES | AstraZeneca AB (SE) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001021597-A1 | THERAPEUTIC QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2001-03-29 | — | — | WO | disclosed |