Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 7/20 | 0.86 |
| ▸ | EGFR | P00533 | 11/20 | 0.79 |
| ▸ | KDR | P35968 | 8/20 | 0.76 |
| ▸ | LCK | P06239 | 2/20 | 0.75 |
| ▸ | RET | P07949 | 2/20 | 0.75 |
| ▸ | MET | P08581 | 2/20 | 0.75 |
| ▸ | MAPT | P10636 | 2/20 | 0.75 |
| ▸ | LTK | P29376 | 2/20 | 0.75 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.75 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.75 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.75 |
| ▸ | CIT | O14578 | 1/20 | 0.75 |
| ▸ | GAK | O14976 | 1/20 | 0.75 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.75 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.75 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.75 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.75 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.75 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.75 |
| ▸ | STK17B | O94768 | 1/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28424819 | 0.92 | SRC (0.85) | SRCEGFRKDRLCKRET | |
| SCHEMBL13529060 | 0.92 | SRC (0.84) | SRCEGFRKDRLCKRET | |
| SCHEMBL5652477 | 0.90 | SRC (0.78) | SRCEGFRKDRLCKRET | |
| SCHEMBL22667930 | 0.90 | EGFR (0.82) | SRCEGFRKDRLCKRET | |
| SCHEMBL5651634 | 0.89 | SRC (0.72) | SRCEGFRKDRLCKRET | |
| SCHEMBL19154598 | 0.89 | SRC (0.80) | SRCEGFRKDRLCKRET | |
| SCHEMBL6692082 | 0.89 | SRC (0.79) | SRCEGFRKDRLCKRET | |
| SCHEMBL6704281 | 0.89 | EGFR (0.80) | SRCEGFRKDRLCKRET | |
| SCHEMBL22383954 | 0.88 | EGFR (0.86) | SRCEGFRKDRLCKRET | |
| SCHEMBL11304 | 0.88 | EGFR (0.86) | SRCEGFRKDRLCKRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7709479-B1 | Quinazoline derivatives and their use as pharmaceuticals | ASTRAZENECA (SE) | 2010-05-04 | — | — | US | disclosed |
| EP-1218354-A1 | QUINAZOLINE DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | AstraZeneca AB (SE) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001021596-A1 | QUINAZOLINE DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | ASTRAZENECA AB (SE) | 2001-03-29 | — | — | WO | disclosed |