Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.67 |
| ▸ | SYK | P43405 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.43 |
| ▸ | CTSL | P07711 | 1/20 | 0.42 |
| ▸ | CTSB | P07858 | 1/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.41 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.41 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.41 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.40 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.40 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5651574 | 0.87 | MEN1 (0.82) | MEN1KMT2AMAPTNPSR1MAPK1 | |
| SCHEMBL14474303 | 0.85 | KMT2A (0.72) | MEN1KMT2ASYKMAPTNPSR1 | |
| SCHEMBL30078294 | 0.80 | KMT2A (1.00) | MEN1KMT2AMAPTNPSR1MAPK1 | |
| SCHEMBL1167690 | 0.80 | KMT2A (1.00) | MEN1KMT2AMAPTNPSR1MAPK1 | |
| SCHEMBL5651180 | 0.77 | MEN1 (0.65) | MEN1KMT2AMAPTNPSR1MAPK1 | |
| SCHEMBL1168174 | 0.75 | MEN1 (0.61) | MEN1KMT2AGSK3B | |
| SCHEMBL5653865 | 0.74 | MEN1 (0.84) | MEN1KMT2AMAPTNPSR1MAPK1 | |
| SCHEMBL2940825 | 0.74 | SMN1; SMN2 (0.48) | SYKMAPTNPSR1MAPK1NOD2 | |
| SCHEMBL1167880 | 0.73 | KMT2A (0.66) | MEN1KMT2AMAPT | |
| SCHEMBL1167168 | 0.72 | MEN1 (0.76) | MEN1KMT2AMAPTNPSR1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7250432-B2 | Pharmaceutical compositions of diaryl-isoxazole derivatives for the prevention and treatment of cancers | KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY (KR) | 2007-07-31 | — | — | US | claimed |
| US-20050131036-A1 | Pharmaceutical compositions of diaryl-isoxazole derivatives for the prevention and treatment of cancers | KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY (KR) | 2005-06-16 | — | — | US | claimed |
| US-7250432-B2 | Pharmaceutical compositions of diaryl-isoxazole derivatives for the prevention and treatment of cancers | KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY (KR) | 2007-07-31 | — | — | US | disclosed |
| US-7250432-B2 | Pharmaceutical compositions of diaryl-isoxazole derivatives for the prevention and treatment of cancers | KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY (KR) | 2007-07-31 | — | — | US | disclosed |
| US-20050131036-A1 | Pharmaceutical compositions of diaryl-isoxazole derivatives for the prevention and treatment of cancers | KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY (KR) | 2005-06-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050131036-A1 | Pharmaceutical compositions of diaryl-isoxazole derivatives for the prevention and treatment of cancers | UACA, SQLE, ALDH1A2 | MEN1 3914/4885KMT2A 4307/4885SYK 765/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.