Sugi Predict

Sugi Predict / Compounds / SCHEMBL565231

SCHEMBL565231

SCHEMBL565231

CC(C)CN(Cc1cc(Cl)c2c(c1)OCCCO2)C(=O)[C@H](C)NCCc1ccccc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PROKR2 Q8NFJ6 5/20 0.53
▸ ALDH1A1 P00352 4/20 0.41
▸ NPC1 O15118 7/20 0.40
▸ KLF5 Q13887 3/20 0.40
▸ PKM P14618 1/20 0.40
▸ PAX8 Q06710 1/20 0.40
▸ RAB9A P51151 6/20 0.38
▸ SMN1; SMN2 Q16637 5/20 0.38
▸ HPGD P15428 2/20 0.38
▸ MAPK8 P45983 1/20 0.37
▸ HDAC3 O15379 1/20 0.37
▸ HDAC4 P56524 1/20 0.37
▸ HDAC1 Q13547 1/20 0.37
▸ HDAC7 Q8WUI4 1/20 0.37
▸ HDAC2 Q92769 1/20 0.37
▸ HDAC8 Q9BY41 1/20 0.37
▸ HDAC9 Q9UKV0 1/20 0.37
▸ HDAC5 Q9UQL6 1/20 0.37
▸ MAPK1 P28482 1/20 0.36
▸ TDP1 Q9NUW8 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10106665 1.00 PROKR2 (0.53) PROKR2ALDH1A1NPC1KLF5PKM
SCHEMBL565921 1.00 PROKR2 (0.53) PROKR2ALDH1A1NPC1KLF5PKM
SCHEMBL565858 0.92 PROKR2 (0.56) PROKR2ALDH1A1NPC1RAB9ASMN1; SMN2
SCHEMBL565475 0.92 PROKR2 (0.56) PROKR2ALDH1A1NPC1RAB9ASMN1; SMN2
SCHEMBL10119874 0.92 PROKR2 (0.56) PROKR2ALDH1A1NPC1RAB9ASMN1; SMN2
SCHEMBL13284391 0.91 PROKR2 (0.44) PROKR2ALDH1A1NPC1KLF5PKM
SCHEMBL565457 0.83 PROKR2 (0.49) PROKR2ALDH1A1NPC1KLF5PKM
SCHEMBL565109 0.83 PROKR2 (0.69) PROKR2ALDH1A1NPC1RAB9ASMN1; SMN2
SCHEMBL565524 0.83 PROKR2 (0.69) PROKR2ALDH1A1NPC1RAB9ASMN1; SMN2
SCHEMBL15693909 0.83 PROKR2 (0.69) PROKR2ALDH1A1NPC1RAB9ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8722896-B2 Prokineticin receptor antagonists and uses thereof THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2014-05-13 — — US disclosed
US-8722896-B2 Prokineticin receptor antagonists and uses thereof THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2014-05-13 — — US disclosed
US-8722896-B2 Prokineticin receptor antagonists and uses thereof THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2014-05-13 — — US disclosed
US-20120035149-A1 Prokineticin Receptor Antagonists And Uses Thereof THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2012-02-09 — — US disclosed
US-20120035149-A1 Prokineticin Receptor Antagonists And Uses Thereof THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2012-02-09 — — US disclosed
US-20120035149-A1 Prokineticin Receptor Antagonists And Uses Thereof THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2012-02-09 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120035149-A1 Prokineticin Receptor Antagonists And Uses Thereof PROKR2, PROKR1, GIPR PROKR2 1/4885ALDH1A1 4725/4885NPC1 3472/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.