Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 10/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | EDNRB | P24530 | 7/20 | 0.34 |
| ▸ | EDNRA | P25101 | 7/20 | 0.34 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 4/20 | 0.33 |
| ▸ | CA1 | P00915 | 4/20 | 0.33 |
| ▸ | CA7 | P43166 | 4/20 | 0.33 |
| ▸ | CA9 | Q16790 | 3/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | CTSG | P08311 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.33 |
| ▸ | PRKCI | P41743 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1164460 | 0.89 | CA2 (0.47) | CA2SMN1; SMN2EDNRBEDNRACA12 | |
| SCHEMBL4765907 | 0.87 | CA2 (0.49) | CA2SMN1; SMN2CA12CA1CA7 | |
| SCHEMBL5655444 | 0.86 | CA2 (0.42) | CA2SMN1; SMN2PTGES2CA12CA1 | |
| SCHEMBL9663047 | 0.80 | CA2 (0.38) | CA2EDNRBEDNRAPTGES2CA12 | |
| SCHEMBL7652735 | 0.79 | ELANE (0.37) | CA2SMN1; SMN2EDNRBEDNRACA12 | |
| SCHEMBL7217744 | 0.77 | CA2 (0.46) | CA2EDNRBEDNRACA12CA1 | |
| SCHEMBL10464956 | 0.76 | CA2 (0.31) | CA2PTGES2CA1 | |
| SCHEMBL4358027 | 0.76 | CA2 (0.41) | CA2CA12CA1CA7CA9 | |
| SCHEMBL5200235 | 0.76 | GAA (0.39) | CA2SMN1; SMN2EDNRBEDNRACA12 | |
| SCHEMBL5512456 | 0.76 | CA2 (0.39) | CA2EDNRBEDNRAPTGES2CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7084170-B2 | Thiophene-amd thiazolesulfonamides as antineoplastic agents | ELI LILLY AND COMPANY (US) | 2006-08-01 | — | — | US | disclosed |