Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | IL1B | P01584 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | XIAP | P98170 | 1/20 | 0.40 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4659466 | 0.83 | ALDH1A1 (0.46) | ALDH1A1SMN1; SMN2KMT2AMEN1IL1B | |
| SCHEMBL14349117 | 0.80 | TACR1 (0.52) | — | |
| SCHEMBL14349121 | 0.78 | TACR1 (0.48) | ALDH1A1KDM4E | |
| SCHEMBL4658279 | 0.77 | IL1B (0.50) | ALDH1A1SMN1; SMN2KMT2AMEN1IL1B | |
| SCHEMBL14349122 | 0.77 | PSEN1 (0.46) | ALDH1A1SMN1; SMN2LMNAKDM4EXIAP | |
| Trifluoroacetic Acid SCHEMBL4659454 | 0.75 | IL1B (0.44) | ALDH1A1SMN1; SMN2KMT2AMEN1IL1B | |
| SCHEMBL4658243 | 0.75 | KMT2A (0.48) | ALDH1A1SMN1; SMN2KMT2AMEN1HTT | |
| SCHEMBL4658238 | 0.73 | KDM4E (0.47) | ALDH1A1SMN1; SMN2KMT2AMEN1HTT | |
| SCHEMBL8620986 | 0.72 | MEN1 (0.73) | ALDH1A1SMN1; SMN2KMT2AMEN1HTT | |
| SCHEMBL7370108 | 0.70 | PTPN1 (0.67) | ALDH1A1SMN1; SMN2KMT2AMEN1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070293492-A1 | Quinoline Tachykinin Receptor Antagonists | MERCK SHARP & DOHME CORP. | 2007-12-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070293492-A1 | Quinoline Tachykinin Receptor Antagonists | TACR1, TACR2, NPSR1 | ALDH1A1 874/4885SMN1; SMN2 3874/4885KMT2A 1330/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.