SCHEMBL5652701

SCHEMBL5652701

Cc1cc2nc(-c3ccc(C(=O)NCCCN4CCOCC4)cc3F)[nH]c2cc1Cl

nearest known ligand 0.52

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
MET P08581 1/20 0.51
L3MBTL1 Q9Y468 1/20 0.50
TNKS2 Q9H2K2 1/20 0.49
ALDH1A1 P00352 1/20 0.48
MAPK14 Q16539 1/20 0.47
CYP2C9 P11712 2/20 0.47
CYP2D6 P10635 1/20 0.47
CDK1 P06493 1/20 0.47
CCNB1 P14635 1/20 0.47
CCNA2 P20248 1/20 0.47
CDK2 P24941 1/20 0.47
POLB P06746 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5652697 0.97 MET (0.51) METL3MBTL1TNKS2ALDH1A1MAPK14
SCHEMBL5652745 0.94 MET (0.52) METALDH1A1CYP2C9CYP2D6
SCHEMBL5653782 0.93 TNKS2 (0.51) METTNKS2ALDH1A1MAPK14CYP2C9
SCHEMBL5653211 0.93 MET (0.51) METALDH1A1CYP2C9CYP2D6
SCHEMBL5653202 0.91 MET (0.51) METALDH1A1CYP2C9CYP2D6
SCHEMBL5651685 0.91 MET (0.51) METL3MBTL1TNKS2ALDH1A1MAPK14
SCHEMBL5652228 0.91 TNKS2 (0.49) METTNKS2ALDH1A1MAPK14CYP2C9
SCHEMBL5653779 0.90 TNKS2 (0.51) METTNKS2MAPK14CYP2C9CYP2D6
SCHEMBL5648672 0.89 CYP2D6 (0.59) METTNKS2ALDH1A1MAPK14CYP2C9
SCHEMBL5651675 0.89 MET (0.51) METL3MBTL1TNKS2ALDH1A1MAPK14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7220769-B2 Azolylbenzamides and analogues and their use for treating osteoporosis NIKEM RESEARCH S.R.L. (IT) 2007-05-22 US disclosed
US-20050038095-A1 Azolylbenzamides and analogues and their use for treating osteoporosis 3-V BIOSCIENCES, INC. 2005-02-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050038095-A1 Azolylbenzamides and analogues and their use for treating osteoporosis NR0B2, NR0B1, NCOR1 MET 1722/4885L3MBTL1 1534/4885TNKS2 2981/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.