Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | LDHA | P00338 | 2/20 | 0.47 |
| ▸ | IDO1 | P14902 | 1/20 | 0.47 |
| ▸ | TDO2 | P48775 | 1/20 | 0.47 |
| ▸ | ASIC3 | Q9UHC3 | 2/20 | 0.47 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.47 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.47 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.47 |
| ▸ | MIF | P14174 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.46 |
| ▸ | GSK3A | P49840 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | TOP1 | P11387 | 1/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.43 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.43 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23300442 | 0.87 | MEN1 (0.53) | NPC1RAB9AKDM4ESMN1; SMN2IDO1 | |
| SCHEMBL18015292 | 0.86 | NPC1 (0.43) | NPC1RAB9AKDM4ESMN1; SMN2LDHA | |
| SCHEMBL21202848 | 0.84 | IDO1 (0.44) | NPC1RAB9AKDM4ESMN1; SMN2LDHA | |
| SCHEMBL31414052 | 0.84 | NPC1 (0.66) | NPC1RAB9ASMN1; SMN2IDO1TDO2 | |
| SCHEMBL117744 | 0.83 | LDHA (0.64) | NPC1RAB9AKDM4ESMN1; SMN2LDHA | |
| SCHEMBL28610327 | 0.83 | NPC1 (0.51) | NPC1RAB9AKDM4ESMN1; SMN2LDHA | |
| SCHEMBL29604379 | 0.83 | LDHA (0.64) | NPC1RAB9AKDM4ESMN1; SMN2LDHA | |
| SCHEMBL25100841 | 0.82 | NPC1 (0.41) | NPC1RAB9AKDM4ESMN1; SMN2LDHA | |
| SCHEMBL18015464 | 0.82 | MAPK1 (0.55) | NPC1RAB9AKDM4ESMN1; SMN2LDHA | |
| SCHEMBL14988841 | 0.81 | LDHA (0.62) | NPC1RAB9AKDM4ESMN1; SMN2LDHA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070249702-A1 | CALCILYTIC COMPOUNDS | GLAXOSMITHKLINE LLC | 2007-10-25 | — | — | US | disclosed |
| US-4026860-A | AROMATIZATION CATALYST | HERCULES INCORPORATED (US) | 1977-05-31 | — | — | US | disclosed |
| US-4026859-A | AROMATIZATION CATALYST | HERCULES INCORPORATED (US) | 1977-05-31 | — | — | US | disclosed |
| US-4026861-A | AROMATIZATION CATALYST | HERCULES INCORPORATED (US) | 1977-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070249702-A1 | CALCILYTIC COMPOUNDS | CALCR, CASR, ORAI1 | NPC1 1137/4885RAB9A 939/4885KDM4E 4732/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.