Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 12/20 | 0.70 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.68 |
| ▸ | KDR | P35968 | 2/20 | 0.62 |
| ▸ | MET | P08581 | 6/20 | 0.62 |
| ▸ | AXL | P30530 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6380294 | 0.95 | FLT3 (0.64) | FLT3PDGFRAKDRMETAXL | |
| SCHEMBL5652832 | 0.89 | KDR (0.65) | FLT3PDGFRAKDRMET | |
| SCHEMBL6376965 | 0.86 | FLT3 (0.79) | FLT3PDGFRAKDRMETAXL | |
| Hydrochloric Acid SCHEMBL5653983 | 0.86 | FLT3 (0.78) | FLT3PDGFRAKDRMETAXL | |
| SCHEMBL6380290 | 0.85 | FLT3 (0.54) | FLT3PDGFRAKDRMETAXL | |
| SCHEMBL5652690 | 0.84 | FLT3 (0.76) | FLT3PDGFRAKDRMETAXL | |
| SCHEMBL5653905 | 0.83 | KDR (0.74) | FLT3PDGFRAKDRMETAXL | |
| SCHEMBL20434905 | 0.82 | FLT3 (1.00) | FLT3 | |
| SCHEMBL698529 | 0.82 | AXL (0.66) | FLT3PDGFRAKDRMETAXL | |
| SCHEMBL5056203 | 0.82 | PDGFRA (0.72) | FLT3PDGFRAKDRMETAXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1652847-A1 | Quinoline and quinazoline derivatives for the treatment of tumors | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-05-03 | — | — | EP | claimed |
| US-7211587-B2 | Quinoline derivatives and quinazoline derivatives having azolyl group | KIRIN BEER KABUSHIKI KAISHA (KR) | 2007-05-01 | — | — | US | disclosed |
| EP-1652847-A1 | Quinoline and quinazoline derivatives for the treatment of tumors | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-05-03 | — | — | EP | disclosed |
| US-6821987-B2 | 4-SUBSTITUTED BY AZOLYLUREIDO-PHENOXY, OR PHENYLTHIO; ANTITUMOR AGENTS; TREATING DIABETIC RETINOPATHY, CHRONIC RHEUMATISM, PSORIASIS, ATHEROSCLEROSIS, | KIRIN BEER KABUSHIKI KAISHA (JP) | 2004-11-23 | — | — | US | disclosed |
| US-20040229876-A1 | Quinoline derivatives and quinazoline derivatives having azolyl group | KIRIN BEER KABUSHIKI KAISHA (JP) | 2004-11-18 | — | — | US | disclosed |
| US-20030087907-A1 | Quinoline derivatives and quinazoline derivatives having azolyl group | KIRIN BEER KABUSHIKI KAISHA (JP) | 2003-05-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040229876-A1 | Quinoline derivatives and quinazoline derivatives having azolyl group | NQO2, H1-5, NRAS | FLT3 83/4885PDGFRA 4104/4885KDR 3455/4885 |
| US-20030087907-A1 | Quinoline derivatives and quinazoline derivatives having azolyl group | NQO2, H1-5, NRAS | FLT3 83/4885PDGFRA 4104/4885KDR 3455/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.