Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 9/20 | 0.54 |
| ▸ | MET | P08581 | 9/20 | 0.53 |
| ▸ | KDR | P35968 | 2/20 | 0.53 |
| ▸ | AXL | P30530 | 1/20 | 0.53 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5653628 | 0.85 | FLT3 (0.70) | FLT3METKDRAXLPDGFRA | |
| SCHEMBL6380294 | 0.81 | FLT3 (0.64) | FLT3METKDRAXLPDGFRA | |
| SCHEMBL5652832 | 0.75 | KDR (0.65) | FLT3METKDRPDGFRACYP3A4 | |
| SCHEMBL698529 | 0.75 | AXL (0.66) | FLT3METKDRAXLPDGFRA | |
| SCHEMBL5056203 | 0.74 | PDGFRA (0.72) | FLT3METKDRAXLPDGFRA | |
| SCHEMBL6376965 | 0.74 | FLT3 (0.79) | FLT3METKDRAXLPDGFRA | |
| Hydrochloric Acid SCHEMBL5653983 | 0.73 | FLT3 (0.78) | FLT3METKDRAXLPDGFRA | |
| SCHEMBL19373219 | 0.73 | PDGFRA (0.69) | FLT3METKDRAXLPDGFRA | |
| SCHEMBL2744790 | 0.73 | PDGFRA (0.69) | FLT3METKDRAXLPDGFRA | |
| SCHEMBL5653905 | 0.73 | KDR (0.74) | FLT3METKDRAXLPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1382604-B1 | QUINOLINE DERIVATIVE HAVING AZOLYL GROUP AND QUINAZOLINE DERIVATIVE | KIRIN BREWERY (JP) | 2005-12-28 | — | — | EP | disclosed |
| EP-1382604-A1 | QUINOLINE DERIVATIVE HAVING AZOLYL GROUP AND QUINAZOLINE DERIVATIVE | KIRIN BEER KABUSHIKI KAISHA (JP) | 2004-01-21 | — | — | EP | disclosed |