Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 2/20 | 0.62 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.50 |
| ▸ | ESR1 | P03372 | 2/20 | 0.50 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.48 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.47 |
| ▸ | CAMKK1 | Q8N5S9 | 1/20 | 0.44 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.44 |
| ▸ | PELI1 | Q96FA3 | 1/20 | 0.44 |
| ▸ | ACVR1 | Q04771 | 4/20 | 0.44 |
| ▸ | IKBKB | O14920 | 1/20 | 0.44 |
| ▸ | CHUK | O15111 | 1/20 | 0.44 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | PAK4 | O96013 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.44 |
| ▸ | IGF1R | P08069 | 1/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16585910 | 0.98 | PIK3CA (0.60) | PIK3CAESR2ESR1ALOX5TLR8 | |
| SCHEMBL9154969 | 0.86 | TLR8 (0.61) | PIK3CAESR2ESR1ALOX5TLR8 | |
| SCHEMBL9709110 | 0.82 | PIK3CA (0.87) | PIK3CACAMKK1CAMKK2ACVR1IKBKB | |
| SCHEMBL529894 | 0.81 | PIK3CA (0.64) | PIK3CATLR8CAMKK1CAMKK2ACVR1 | |
| SCHEMBL12277881 | 0.79 | PIK3CA (0.62) | PIK3CAACVR1IKBKBCHUKDAPK3 | |
| SCHEMBL30440259 | 0.79 | PIK3CA (0.62) | PIK3CAACVR1IKBKBCHUKDAPK3 | |
| SCHEMBL8956040 | 0.79 | PIK3CA (0.62) | PIK3CATLR8ACVR1IKBKBCHUK | |
| SCHEMBL9806116 | 0.79 | PIK3CA (0.62) | PIK3CACAMKK1CAMKK2ACVR1IKBKB | |
| SCHEMBL9907326 | 0.79 | PIK3CA (0.57) | PIK3CACAMKK1CAMKK2MAP4K4MAPT | |
| SCHEMBL27278122 | 0.79 | BMP4 (0.57) | PIK3CAESR1TLR8CAMKK1CAMKK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070293492-A1 | Quinoline Tachykinin Receptor Antagonists | MERCK SHARP & DOHME CORP. | 2007-12-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070293492-A1 | Quinoline Tachykinin Receptor Antagonists | TACR1, TACR2, NPSR1 | PIK3CA 1852/4885ESR2 1788/4885ESR1 1171/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.