Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | PDE4A | P27815 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.50 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.31 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.31 |
| ▸ | NCF1 | P14598 | 1/20 | 0.31 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piperazine SCHEMBL9284358 | 1.00 | HIF1A (0.50) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperidine SCHEMBL9353467 | 0.82 | ALDH1A1 (0.60) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL28605103 | 0.82 | HIF1A (0.40) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL192250 | 0.82 | HIF1A (0.40) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL28017070 | 0.79 | HIF1A (0.38) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL27985317 | 0.79 | HIF1A (0.38) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL27991446 | 0.79 | HIF1A (0.38) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL27552148 | 0.75 | HIF1A (0.50) | HIF1AMAPTPDE4AKDRCXCR4 | |
| SCHEMBL13281 | 0.71 | — | — | |
| SCHEMBL1505178 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6998272-B2 | Macrocyclic compounds and their use | PROMETIC BIOSCIENCES, LTD. (GB) | 2006-02-14 | — | — | US | disclosed |
| US-20040115724-A1 | Macrocyclic compounds and their use | PROMETIC BIOSCIENCES LTD. (GB) | 2004-06-17 | — | — | US | disclosed |
| EP-1240150-A1 | MACROCYCLIC COMPOUNDS AND THEIR USE | Prometic Biosciences Ltd (GB) | 2002-09-18 | — | — | EP | disclosed |
| WO-2001042228-A1 | MACROCYCLIC COMPOUNDS AND THEIR USE | PROMETIC BIOSCIENCES LTD. (GB) | 2001-06-14 | — | — | WO | disclosed |