⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8329675 | 1.00 | — | — | |
| SCHEMBL19730165 | 0.75 | — | — | |
| SCHEMBL8324768 | 0.75 | — | — | |
| SCHEMBL3696578 | 0.73 | — | — | |
| SCHEMBL11288135 | 0.67 | — | — | |
| SCHEMBL11287028 | 0.67 | ALDH1A1 (0.31) | — | |
| SCHEMBL11287030 | 0.67 | ALDH1A1 (0.31) | — | |
| SCHEMBL19120267 | 0.66 | — | — | |
| SCHEMBL14629631 | 0.62 | POLB (0.33) | — | |
| SCHEMBL18902422 | 0.62 | POLB (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111087284-A | Preparation method of beraprost intermediate | 安庆润科生物医药科技有限公司 | 2020-05-01 | — | — | CN | claimed |
| US-4001308-A | REACTION OF DIBROMO COMPOUND WITH METAL SALT OF ACETIC ACID | TEIJIN LIMITED (JA) | 1977-01-04 | — | — | US | claimed |
| CN-111087284-A | Preparation method of beraprost intermediate | 安庆润科生物医药科技有限公司 | 2020-05-01 | — | — | CN | disclosed |
| CN-111087284-A | Preparation method of beraprost intermediate | 安庆润科生物医药科技有限公司 | 2020-05-01 | — | — | CN | disclosed |
| CN-110452100-A | A kind of synthetic method of beraprost sodium intermediate | JINAN KANGHE MEDICAL TECH CO LTD | 2019-11-15 | — | — | CN | disclosed |
| WO-2017174439-A1 | PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE BERAPROST | CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. (HU) | 2017-10-12 | — | — | WO | disclosed |
| US-20070149481-A1 | N,n-bridged, nitrogen-substituted carbacyclic indolocarbazoles as protein kinase inhibitors | NAD AG (DE) | 2007-06-28 | — | — | US | disclosed |
| EP-1565473-B1 | N,N-BRIDGED, NITROGEN-SUBSTITUTED CARBACYCLIC INDOLOCARBAZOLES AS PROTEIN KINASE INHIBITORS | NAD AG (DE) | 2006-08-02 | — | — | EP | disclosed |
| EP-1565473-A1 | N,N-BRIDGED, NITROGEN-SUBSTITUTED CARBACYCLIC INDOLOCARBAZOLES AS PROTEIN KINASE INHIBITORS | Nad AG (DE) | 2005-08-24 | — | — | EP | disclosed |
| WO-2004048384-A1 | N,N-BRIDGED, NITROGEN-SUBSTITUTED CARBACYCLIC INDOLOCARBAZOLES AS PROTEIN KINASE INHIBITORS | NAD AG (DE) | 2004-06-10 | — | — | WO | disclosed |
| EP-0915073-B1 | PROCESS FOR PRODUCING OPTICALLY ACTIVE ISOMERS OF TRICYCLIC COMPOUNDS | TORAY INDUSTRIES (JP) | 2003-08-13 | — | — | EP | disclosed |
| EP-0000555-B1 | PROCESS FOR THE PREPARATION OF OXIRANES SUBSTITUTED BY HALOGEN ALKYL | BAYER AG (DE) | 1982-02-10 | — | — | EP | disclosed |
| EP-0000554-B1 | PROCESS FOR THE PREPARATION OF OXIRANES SUBSTITUTED BY HALOGEN ALKYL | BAYER AG (DE) | 1982-02-10 | — | — | EP | disclosed |
| US-4301164-A | FOR USE AS ANTIULCER AGENTS, HYPOTENSIVE AGENTS, ANTITHROMBOSIC AGENTS | TORAY INDUSTRIES, INC. (JP) | 1981-11-17 | — | — | US | disclosed |
| EP-0024943-A1 | 5,6,7-Trinor-4,8-inter-m-phenylene PGI2 derivatives and pharmaceutical compositions containing them | TORAY INDUSTRIES, INC. (JP) | 1981-03-11 | — | — | EP | disclosed |
| EP-0000554-A1 | Process for the preparation of oxiranes substituted by halogen alkyl | BAYER AG (DE) | 1979-02-07 | — | — | EP | disclosed |
| US-4008125-A | New cyclopentene-diols and new acyl esters thereof and process for their preparation | TEIJIN LIMITED (JA) | 1977-02-15 | — | — | US | disclosed |
| US-4001308-A | REACTION OF DIBROMO COMPOUND WITH METAL SALT OF ACETIC ACID | TEIJIN LIMITED (JA) | 1977-01-04 | — | — | US | disclosed |
| US-4001308-A | REACTION OF DIBROMO COMPOUND WITH METAL SALT OF ACETIC ACID | TEIJIN LIMITED (JA) | 1977-01-04 | — | — | US | disclosed |
| US-3932564-A | CATIONIC POLYMERS, ELECTROGRAPHY | MONSANTO COMPANY (US) | 1976-01-13 | — | — | US | disclosed |