SCHEMBL5655051

SCHEMBL5655051

COc1cc(Cc2ccc(S(=O)(=O)N=C=O)c(OC)c2)ccc1N=C=O

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.50
CYP3A4 P08684 2/20 0.50
HPGD P15428 1/20 0.50
TDP1 Q9NUW8 1/20 0.50
CA2 P00918 2/20 0.40
GAA P10253 1/20 0.34
TSHR P16473 1/20 0.33
TUBB4A P04350 1/20 0.33
TUBB P07437 1/20 0.33
TUBA3C P0DPH7 1/20 0.33
TUBA1B P68363 1/20 0.33
TUBA4A P68366 1/20 0.33
TUBB4B P68371 1/20 0.33
TUBB3 Q13509 1/20 0.33
TUBB2A Q13885 1/20 0.33
TUBB8 Q3ZCM7 1/20 0.33
TUBA3E Q6PEY2 1/20 0.33
TUBA1A Q71U36 1/20 0.33
TUBA1C Q9BQE3 1/20 0.33
TUBB6 Q9BUF5 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8099990 0.86 HPGD (0.70) ALDH1A1CYP3A4HPGDTDP1CA2
SCHEMBL374656 0.85 ALDH1A1 (0.67) ALDH1A1CYP3A4HPGDTDP1CA2
SCHEMBL181315 0.79 CYP3A4 (0.59) ALDH1A1CYP3A4HPGDTDP1CA2
SCHEMBL11668310 0.79 CYP3A4 (0.59) ALDH1A1CYP3A4HPGDTDP1CA2
SCHEMBL16313427 0.78 ALDH1A1 (0.56) ALDH1A1CYP3A4HPGDTDP1CA2
SCHEMBL483572 0.77 ALDH1A1 (0.59) ALDH1A1CYP3A4HPGDTDP1CA2
SCHEMBL17787467 0.76 CYP3A4 (0.67) ALDH1A1CYP3A4HPGDTDP1CA2
SCHEMBL19308541 0.74 CYP3A4 (0.63) ALDH1A1CYP3A4HPGDTDP1CA2
SCHEMBL1071456 0.73 CA2 (0.53) ALDH1A1CYP3A4HPGDTDP1CA2
SCHEMBL1683896 0.73 CYP3A4 (0.54) ALDH1A1CYP3A4HPGDTDP1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7030274-B2 Process for the production of carbodiimide modified organic isocyanates BAYER MATERIALSCIENCE LLC (US) 2006-04-18 US disclosed
US-20050282993-A1 Process for the production of carbodiimide modified organic isocyanates COVESTRO LLC 2005-12-22 US disclosed
EP-1607425-A1 Process for the production of carboiimide modified organic isocyanates Bayer MaterialScience LLC (US) 2005-12-21 EP disclosed
US-6362247-B1 DEACTIVATION PHOSPHOLENE CATALYSTS ROHM AND HAAS COMPANY 2002-03-26 US disclosed
EP-1054029-A1 Method of improving stability of aromatic polycarbodimides ROHM AND HAAS COMPANY (US) 2000-11-22 EP disclosed
US-5045226-A Reaction product of tin compound with sulfonyl isocyanate, storage stability, polyurethanes BAYER AKTIENGESELLSCHAFT (DE) 1991-09-03 US disclosed
EP-0232541-B1 POLYISOCYANATE COMPOSITIONS CONTAINING LATENT TIN-CATALYSTS, THEIR USE IN THE PREPARATION OF POLYURETHANE RESINS AND REACTION PRODUCTS OF SULFONYL ISOCYANATES WITH SELECTED TIN COMPOUNDS BAYER AG (DE) 1990-10-24 EP disclosed
EP-0173252-B1 PROCESS FOR THE PREPARATION OF OLIGOMERIC POLYISOCYANATES AND THEIR USE IN THE PREPARATION OF POLYURETHANE PLASTICS BAYER AG (DE) 1989-07-26 EP disclosed
US-4824595-A Polyisocyanate compositions containing reversibly blocked catalysts and addition products of sulfonyl isocyanates with catalysts having a tin(II)- or tin(IV)-carboxylate structure BAYER AKTIENGESELLSCHAFT (DE) 1989-04-25 US disclosed
EP-0172379-B1 MATERIAL FOR ORTHOPAEDIC BANDAGES BAYER AG (DE) 1989-04-19 EP disclosed
EP-0132675-B1 PREPARATIONS OF POLYISOCYNATE CONTAINING REVERSIBLY BLOCKED CATALYSTS, PROCESS FOR THEIR PRODUCTION, THEIR USE IN THE PRODUCTION OF POLYURETHANES, AND ADDITION PRODUCTS OF SULFONYLISOCYANATES ON CATALYSTS WITH A STRUCTURE OF CARBOXYLATES OF TIN II OR IV BAYER AG (DE) 1988-12-07 EP disclosed
US-4638795-A FOR MEDICAL AND VETERINARY USE; BASED ON POLYURETHANES BAYER AKTIENGESELLSCHAFT (DE) 1987-01-27 US disclosed
US-4614785-A TERTIARY PHOSPHINE OR PERALKYLATED PHOSPHORUS ACID TRIAMIDE CATALYST BAYER AKTIENGESELLSCHAFT (DE) 1986-09-30 US disclosed
EP-0173252-A2 Process for the preparation of oligomeric polyisocyanates and their use in the preparation of polyurethane plastics BAYER AG (DE) 1986-03-05 EP disclosed
EP-0172379-A1 Material for orthopaedic bandages BAYER AG (DE) 1986-02-26 EP disclosed
EP-0132675-A2 Preparations of polyisocynate containing reversibly blocked catalysts, process for their production, their use in the production of polyurethanes, and addition products of sulfonylisocyanates on catalysts with a structure of carboxylates of tin II or IV BAYER AG (DE) 1985-02-13 EP disclosed