Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEK | Q02763 | 9/20 | 0.53 |
| ▸ | KDR | P35968 | 8/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | UBE2N | P61088 | 1/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | CLK1 | P49759 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Gw642138X SCHEMBL5404724 | 0.73 | EGFR (0.57) | TEKKDRMAP4K4GSK3BEGFR | |
| SCHEMBL14013977 | 0.69 | TEK (0.74) | TEKKDRKDM4EALDH1A1HPGD | |
| SCHEMBL14013972 | 0.69 | TEK (0.74) | TEKKDRKDM4EALDH1A1HPGD | |
| Gw642125X SCHEMBL14013971 | 0.68 | KDR (1.00) | TEKKDRKDM4EALDH1A1HPGD | |
| SCHEMBL14013982 | 0.67 | TEK (0.92) | TEKKDRKDM4EALDH1A1HPGD | |
| SCHEMBL12355051 | 0.66 | KDM4E (1.00) | TEKKDRKDM4EALDH1A1HPGD | |
| SCHEMBL14923113 | 0.66 | KDM4E (1.00) | TEKKDRKDM4EALDH1A1HPGD | |
| SCHEMBL30782553 | 0.64 | TEK (0.54) | TEKKDRKDM4EALDH1A1HPGD | |
| SCHEMBL28001140 | 0.63 | DYRK1A (0.60) | KDM4EALDH1A1SMN1; SMN2MAP4K4NPC1 | |
| SCHEMBL6409547 | 0.62 | EGFR (0.57) | KDRHPGDGSK3BEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070185098-A1 | Inhibitors of protein kinases | LOCUS PHARMACEUTICALS, INC. (US) | 2007-08-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070185098-A1 | Inhibitors of protein kinases | MAP3K20, MAP3K1, MAP3K19 | TEK 1180/4885KDR 960/4885KDM4E 1174/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.