Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 9/20 | 0.57 |
| ▸ | GSK3B | P49841 | 8/20 | 0.57 |
| ▸ | KDR | P35968 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6409156 | 0.83 | HPGD (0.57) | EGFRGSK3BKDRMEN1HPGD | |
| Gw642138X SCHEMBL5404724 | 0.83 | EGFR (0.57) | EGFRGSK3BKDR | |
| SCHEMBL20742179 | 0.81 | GSK3B (0.52) | EGFRGSK3BKDRMEN1HPGD | |
| SCHEMBL759984 | 0.80 | HPGD (0.60) | EGFRGSK3BKDRMEN1HPGD | |
| SCHEMBL5450817 | 0.78 | GSK3B (0.60) | EGFRGSK3BKDR | |
| SCHEMBL5354432 | 0.75 | MEN1 (0.45) | GSK3BKDRMEN1HPGDKMT2A | |
| SCHEMBL6408608 | 0.75 | KDR (0.71) | EGFRGSK3BKDR | |
| SCHEMBL5391001 | 0.73 | GSK3B (1.00) | EGFRGSK3BKDR | |
| SCHEMBL8293366 | 0.71 | GSK3B (1.00) | GSK3BKDR | |
| SCHEMBL9046890 | 0.71 | ALDH1A1 (0.56) | KDRMEN1HPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015000959-A1 | 4-AMINO-6-ARYL[2,3-D]PYRIMIDINES FOR THE INHIBITION OF EGFR TYROSINE KINASE | NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY (NTNU) (NO) | 2015-01-08 | — | — | WO | disclosed |
| WO-2005092896-A1 | COMPOUND FOR INHIBITING TYROSINE KINASE ACTIVITY OF DDR2 PROTEIN | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2005-10-06 | — | — | WO | disclosed |