Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR1 | P25024 | 14/20 | 0.75 |
| ▸ | CXCR2 | P25025 | 14/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | CASP3 | P42574 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.49 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.49 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5658349 | 0.89 | CXCR2 (0.73) | CXCR1CXCR2ALDH1A1P4HTM | |
| SCHEMBL5846287 | 0.86 | CXCR1 (1.00) | CXCR1CXCR2ALDH1A1P4HTM | |
| SCHEMBL5659069 | 0.85 | CXCR2 (0.59) | CXCR1CXCR2ALDH1A1MAPTP4HTM | |
| SCHEMBL5660344 | 0.85 | CXCR1 (0.57) | CXCR1CXCR2ALDH1A1P4HTM | |
| SCHEMBL5661579 | 0.85 | CXCR2 (0.57) | CXCR1CXCR2MEN1KMT2AP4HTM | |
| SCHEMBL5659634 | 0.84 | CXCR1 (0.58) | CXCR1CXCR2ALDH1A1P4HTM | |
| SCHEMBL5661096 | 0.84 | CXCR2 (0.67) | CXCR1CXCR2MAPTP4HTM | |
| SCHEMBL5660485 | 0.84 | CXCR2 (0.77) | CXCR1CXCR2POLBMEN1KMT2A | |
| SCHEMBL5659864 | 0.84 | CXCR2 (0.54) | CXCR1CXCR2P4HTM | |
| SCHEMBL5656328 | 0.83 | P4HTM (0.57) | CXCR1CXCR2ALDH1A1P4HTM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7176310-B1 | Pyrimidinecarboxamide derivatives and their use as anti-inflammatory agents | UCB SA (GB) | 2007-02-13 | — | — | US | disclosed |