Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.57 |
| ▸ | CXCR2 | P25025 | 13/20 | 0.56 |
| ▸ | CXCR1 | P25024 | 11/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | MITF | O75030 | 1/20 | 0.51 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.50 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.50 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5658349 | 0.86 | CXCR2 (0.73) | P4HTMCXCR2CXCR1NPC1RAB9A | |
| SCHEMBL5661096 | 0.84 | CXCR2 (0.67) | P4HTMCXCR2CXCR1NPC1RAB9A | |
| SCHEMBL5656795 | 0.84 | CXCR2 (0.76) | P4HTMCXCR2CXCR1NPC1RAB9A | |
| SCHEMBL5846254 | 0.84 | CXCR2 (0.78) | P4HTMCXCR2CXCR1 | |
| SCHEMBL5659069 | 0.83 | CXCR2 (0.59) | P4HTMCXCR2CXCR1NPC1RAB9A | |
| SCHEMBL5656391 | 0.83 | CXCR1 (0.75) | P4HTMCXCR2CXCR1ALDH1A1 | |
| SCHEMBL5659634 | 0.82 | CXCR1 (0.58) | P4HTMCXCR2CXCR1NPC1RAB9A | |
| SCHEMBL5660485 | 0.82 | CXCR2 (0.77) | CXCR2CXCR1NPC1RAB9A | |
| SCHEMBL5658045 | 0.80 | CXCR2 (0.59) | P4HTMCXCR2CXCR1NPC1RAB9A | |
| SCHEMBL5660642 | 0.80 | CXCR2 (0.75) | P4HTMCXCR2CXCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7176310-B1 | Pyrimidinecarboxamide derivatives and their use as anti-inflammatory agents | UCB SA (GB) | 2007-02-13 | — | — | US | disclosed |