Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | GSK3A | P49840 | 1/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.47 |
| ▸ | PRKCA | P17252 | 1/20 | 0.47 |
| ▸ | GRK2 | P25098 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | KDM1A | O60341 | 1/20 | 0.45 |
| ▸ | TACR3 | P29371 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5227468 | 0.93 | MAPT (0.60) | GSK3BMAPTTP53GSK3ADYRK1A | |
| Trifluoroacetic Acid SCHEMBL5657353 | 0.90 | GSK3B (0.58) | GSK3BMAPTTP53ROCK2PRKCA | |
| Trifluoroacetic Acid SCHEMBL5661050 | 0.89 | GSK3B (0.52) | GSK3BMAPTROCK2RXFP1ROCK1 | |
| Trifluoroacetic Acid SCHEMBL5658704 | 0.89 | GSK3B (0.67) | GSK3BMAPTROCK2PRKCAGRK2 | |
| Trifluoroacetic Acid SCHEMBL5655822 | 0.89 | GSK3B (0.59) | GSK3BROCK2PRKCAGRK2HDAC1 | |
| Trifluoroacetic Acid SCHEMBL5657173 | 0.88 | GSK3B (0.58) | GSK3BMAPTROCK2PRKCAGRK2 | |
| SCHEMBL4853063 | 0.87 | GSK3B (0.59) | GSK3BMAPTROCK2PRKCAGRK2 | |
| Trifluoroacetic Acid SCHEMBL5658680 | 0.86 | GSK3B (0.55) | GSK3BROCK2PRKCAGRK2KDM4E | |
| Trifluoroacetic Acid SCHEMBL5656836 | 0.86 | GSK3B (0.56) | GSK3BMAPTTP53ROCK2PRKCA | |
| Trifluoroacetic Acid SCHEMBL5657178 | 0.86 | GSK3B (0.58) | GSK3BMAPTROCK2PRKCAGRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7309701-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-12-18 | — | — | US | disclosed |