Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 3/20 | 0.56 |
| ▸ | PPARG | P37231 | 2/20 | 0.45 |
| ▸ | PPARA | Q07869 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | PRKCA | P17252 | 1/20 | 0.41 |
| ▸ | GRK2 | P25098 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | PRKACA | P17612 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5226253 | 0.93 | GSK3B (0.60) | GSK3BPPARGPPARAMAPTTP53 | |
| Trifluoroacetic Acid SCHEMBL5657353 | 0.90 | GSK3B (0.58) | GSK3BMAPTTP53KDM4EPOLB | |
| Trifluoroacetic Acid SCHEMBL5657178 | 0.89 | GSK3B (0.58) | GSK3BPPARGPPARAMAPTKDM4E | |
| Trifluoroacetic Acid SCHEMBL5657921 | 0.88 | GSK3B (0.62) | GSK3BMAPTPOLBCASP1ROCK2 | |
| Trifluoroacetic Acid SCHEMBL5658704 | 0.87 | GSK3B (0.67) | GSK3BMAPTKDM4ECASP1ROCK2 | |
| Trifluoroacetic Acid SCHEMBL5655822 | 0.87 | GSK3B (0.59) | GSK3BPPARASMN1; SMN2CASP1ROCK2 | |
| Trifluoroacetic Acid SCHEMBL5657173 | 0.87 | GSK3B (0.58) | GSK3BMAPTKDM4EPOLBCASP1 | |
| Trifluoroacetic Acid SCHEMBL5656445 | 0.86 | GSK3B (0.55) | GSK3BMAPTTP53KDM4EROCK2 | |
| Trifluoroacetic Acid SCHEMBL5659768 | 0.85 | GSK3B (0.64) | GSK3BPOLBCASP1ROCK2PRKCA | |
| Trifluoroacetic Acid SCHEMBL5659066 | 0.85 | GSK3B (0.59) | GSK3BMAPTCASP1ROCK2PRKCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7309701-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-12-18 | — | — | US | disclosed |