Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 3/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.44 |
| ▸ | KLK1 | P06870 | 1/20 | 0.44 |
| ▸ | PRKCA | P17252 | 1/20 | 0.44 |
| ▸ | GRK2 | P25098 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4848500 | 0.93 | GSK3B (0.62) | GSK3BMAPTSMN1; SMN2MAPK1GAA | |
| Trifluoroacetic Acid SCHEMBL5657178 | 0.92 | GSK3B (0.58) | GSK3BMAPTSMN1; SMN2MAPK1GAA | |
| Trifluoroacetic Acid SCHEMBL5655822 | 0.91 | GSK3B (0.59) | GSK3BSMN1; SMN2CASP1ROCK2PRKCA | |
| Trifluoroacetic Acid SCHEMBL5658704 | 0.91 | GSK3B (0.67) | GSK3BMAPTMAPK1GAACASP1 | |
| Trifluoroacetic Acid SCHEMBL5656836 | 0.90 | GSK3B (0.56) | GSK3BMAPTSMN1; SMN2MAPK1GAA | |
| Trifluoroacetic Acid SCHEMBL5657173 | 0.90 | GSK3B (0.58) | GSK3BMAPTMAPK1GAACASP1 | |
| Trifluoroacetic Acid SCHEMBL5656445 | 0.90 | GSK3B (0.55) | GSK3BMAPTRAB9AROCK2PRKCA | |
| Trifluoroacetic Acid SCHEMBL5658680 | 0.89 | GSK3B (0.55) | GSK3BCASP1ROCK2PRKCAGRK2 | |
| Trifluoroacetic Acid SCHEMBL5659289 | 0.88 | GSK3B (0.63) | GSK3BMAPTSMN1; SMN2MAPK1GAA | |
| Trifluoroacetic Acid SCHEMBL5657921 | 0.87 | GSK3B (0.62) | GSK3BMAPTGAACASP1ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7309701-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-12-18 | — | — | US | disclosed |