Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.44 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.44 |
| ▸ | CASP1 | P29466 | 2/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.42 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.42 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.42 |
| ▸ | PRKCA | P17252 | 2/20 | 0.42 |
| ▸ | GRK2 | P25098 | 2/20 | 0.42 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5229575 | 0.93 | GSK3B (0.64) | GSK3BCYP2C9MAPK1MAPK3CASP1 | |
| SCHEMBL4847310 | 0.85 | GSK3B (0.66) | GSK3BCYP2C9MAPK1MAPK3CASP1 | |
| Trifluoroacetic Acid SCHEMBL5656666 | 0.85 | GSK3B (0.73) | GSK3BMAPK1MAPK3CASP1MAPK13 | |
| Trifluoroacetic Acid SCHEMBL5658531 | 0.85 | GSK3B (0.61) | GSK3BCYP2C9MAPK1CASP1MAPK13 | |
| Trifluoroacetic Acid SCHEMBL5658947 | 0.85 | GSK3B (0.61) | GSK3BCYP2C9CASP1MAPK13MAPK12 | |
| Trifluoroacetic Acid SCHEMBL5660695 | 0.84 | GSK3B (0.73) | GSK3BCYP2C9MAPK1MAPK3CASP1 | |
| Trifluoroacetic Acid SCHEMBL5659124 | 0.83 | GSK3B (0.61) | GSK3BCYP2C9MAPK1MAPK3CASP1 | |
| Trifluoroacetic Acid SCHEMBL5659047 | 0.83 | GSK3B (0.58) | GSK3BCYP2C9CASP1MAPK13MAPK12 | |
| Trifluoroacetic Acid SCHEMBL5657169 | 0.83 | GSK3B (0.61) | GSK3BCYP2C9MAPK1MAPK13MAPK12 | |
| Trifluoroacetic Acid SCHEMBL5660802 | 0.83 | GSK3B (0.61) | GSK3BCYP2C9MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7309701-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-12-18 | — | — | US | disclosed |