Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.49 |
| ▸ | GRK2 | P25098 | 2/20 | 0.49 |
| ▸ | PRKCA | P17252 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.47 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.46 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.46 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5229513 | 0.94 | GSK3B (0.66) | GSK3BALDH1A1ROCK2GRK2PRKCA | |
| Trifluoroacetic Acid SCHEMBL5657169 | 0.91 | GSK3B (0.61) | GSK3BALDH1A1ROCK2ROCK1POLB | |
| Trifluoroacetic Acid SCHEMBL5658531 | 0.88 | GSK3B (0.61) | GSK3BALDH1A1ROCK2HPGDROCK1 | |
| SCHEMBL4853282 | 0.87 | GSK3B (0.65) | GSK3BROCK2ROCK1POLBMAPK13 | |
| Trifluoroacetic Acid SCHEMBL5658947 | 0.86 | GSK3B (0.61) | GSK3BROCK2GRK2PRKCAHPGD | |
| SCHEMBL13986958 | 0.84 | LMNA (0.62) | GSK3BALDH1A1ROCK2HPGDLMNA | |
| Trifluoroacetic Acid SCHEMBL5656445 | 0.84 | GSK3B (0.55) | GSK3BROCK2GRK2PRKCAROCK1 | |
| Trifluoroacetic Acid SCHEMBL5657401 | 0.83 | GSK3B (0.59) | GSK3BROCK2GRK2PRKCAPOLB | |
| Trifluoroacetic Acid SCHEMBL5659784 | 0.83 | GSK3B (0.89) | GSK3BALDH1A1ROCK2ROCK1GAA | |
| SCHEMBL4854813 | 0.82 | GSK3B (0.66) | GSK3BROCK2GRK2PRKCAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7309701-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-12-18 | — | — | US | disclosed |