Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 3/20 | 0.55 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.46 |
| ▸ | PRKCA | P17252 | 1/20 | 0.46 |
| ▸ | GRK2 | P25098 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.44 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 6/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | FLT1 | P17948 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4855854 | 0.93 | GSK3B (0.58) | GSK3BROCK2PRKCAGRK2HDAC1 | |
| Trifluoroacetic Acid SCHEMBL5655822 | 0.90 | GSK3B (0.59) | GSK3BROCK2PRKCAGRK2HDAC1 | |
| Trifluoroacetic Acid SCHEMBL5658704 | 0.88 | GSK3B (0.67) | GSK3BROCK2PRKCAGRK2HDAC1 | |
| Trifluoroacetic Acid SCHEMBL5657353 | 0.87 | GSK3B (0.58) | GSK3BROCK2PRKCAGRK2HDAC1 | |
| Trifluoroacetic Acid SCHEMBL5657173 | 0.87 | GSK3B (0.58) | GSK3BROCK2PRKCAGRK2HDAC1 | |
| SCHEMBL4854602 | 0.85 | GSK3B (0.63) | GSK3BROCK2PRKCAGRK2HDAC1 | |
| SCHEMBL4848978 | 0.84 | GSK3B (0.61) | GSK3BROCK2PRKCAGRK2HDAC1 | |
| Trifluoroacetic Acid SCHEMBL5656445 | 0.84 | GSK3B (0.55) | GSK3BROCK2PRKCAGRK2HDAC1 | |
| Trifluoroacetic Acid SCHEMBL5657921 | 0.84 | GSK3B (0.62) | GSK3BROCK2PRKCAGRK2HDAC1 | |
| Trifluoroacetic Acid SCHEMBL5659768 | 0.84 | GSK3B (0.64) | GSK3BROCK2PRKCAGRK2HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7309701-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-12-18 | — | — | US | disclosed |