Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.43 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.43 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.43 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.43 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.43 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | WDR5 | P61964 | 6/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4848965 | 0.94 | GSK3B (0.66) | GSK3BMAPK1MAPTPSEN1PSEN2 | |
| SCHEMBL4848492 | 0.82 | GSK3B (0.64) | GSK3BMAPK1MAPTADORA2AADORA1 | |
| Trifluoroacetic Acid SCHEMBL5657353 | 0.82 | GSK3B (0.58) | GSK3BMAPK1MAPTLMNA | |
| Trifluoroacetic Acid SCHEMBL5658055 | 0.81 | GSK3B (0.54) | GSK3BMAPK1MAPTWDR5LMNA | |
| SCHEMBL4849023 | 0.81 | GSK3B (0.62) | GSK3BMAPK1MAPTADORA2ALMNA | |
| SCHEMBL4856418 | 0.81 | GSK3B (0.62) | GSK3BMAPK1MAPTADORA2AADORA1 | |
| SCHEMBL4856682 | 0.81 | GSK3B (0.69) | GSK3BMAPTLMNA | |
| Trifluoroacetic Acid SCHEMBL5658704 | 0.79 | GSK3B (0.67) | GSK3BMAPK1MAPTLMNA | |
| Trifluoroacetic Acid SCHEMBL5655822 | 0.79 | GSK3B (0.59) | GSK3B | |
| Trifluoroacetic Acid SCHEMBL5659066 | 0.79 | GSK3B (0.59) | GSK3BMAPK1MAPTWDR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7309701-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-12-18 | — | — | US | disclosed |