Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 11/20 | 0.55 |
| ▸ | PPARA | Q07869 | 9/20 | 0.55 |
| ▸ | PPARG | P37231 | 7/20 | 0.55 |
| ▸ | FFAR1 | O14842 | 6/20 | 0.54 |
| ▸ | HTR6 | P50406 | 1/20 | 0.47 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.46 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6489153 | 0.91 | PPARD (0.53) | PPARDPPARAPPARGFFAR1HTR6 | |
| SCHEMBL5661290 | 0.89 | PPARD (0.55) | PPARDPPARAPPARGFFAR1AKR1A1 | |
| SCHEMBL5660103 | 0.88 | PPARD (0.54) | PPARDPPARAPPARGFFAR1AKR1A1 | |
| SCHEMBL5660147 | 0.87 | PPARD (0.59) | PPARDPPARAPPARGFFAR1PTPN1 | |
| SCHEMBL5658861 | 0.82 | HTR6 (0.46) | PPARDPPARAPPARGFFAR1HTR6 | |
| SCHEMBL5641773 | 0.82 | HTR6 (0.62) | HTR6MAPT | |
| SCHEMBL14605643 | 0.80 | PPARD (0.41) | PPARDPPARAPPARGFFAR1HTR6 | |
| SCHEMBL5659640 | 0.78 | PPARD (0.49) | PPARDPPARAPPARGFFAR1MAPT | |
| SCHEMBL6502357 | 0.77 | FFAR1 (0.48) | PPARDPPARAPPARGFFAR1MAPT | |
| SCHEMBL5662461 | 0.76 | HTR6 (0.44) | PPARDPPARAPPARGFFAR1HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070072904-A1 | 1-arylsulfone-substituted indole carboxylic acids or amides; peroxisome proliferator-activated receptor PPAR modulators; obesity, diabetes, cardiovascular disorders | PLEXXIKON INC | 2007-03-29 | — | — | US | disclosed |
| US-20070072904-A1 | 1-arylsulfone-substituted indole carboxylic acids or amides; peroxisome proliferator-activated receptor PPAR modulators; obesity, diabetes, cardiovascular disorders | PLEXXIKON INC | 2007-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070072904-A1 | 1-arylsulfone-substituted indole carboxylic acids or amides; peroxisome proliferator-activated receptor PPAR modulators; obesity, diabetes, cardiovascular disorders | PPARG, PPARA, PPARD | PPARD 3/4885PPARA 2/4885PPARG 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.