Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 3/20 | 0.55 |
| ▸ | SORT1 | Q99523 | 2/20 | 0.48 |
| ▸ | MLYCD | O95822 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.47 |
| ▸ | GRK2 | P25098 | 2/20 | 0.47 |
| ▸ | PRKCA | P17252 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4848924 | 0.96 | GSK3B (0.59) | GSK3BSORT1MLYCDLMNAHPGD | |
| Trifluoroacetic Acid SCHEMBL5655822 | 0.91 | GSK3B (0.59) | GSK3BSORT1ROCK2GRK2PRKCA | |
| Trifluoroacetic Acid SCHEMBL5656429 | 0.90 | GSK3B (0.64) | GSK3BROCK2GRK2PRKCACASP1 | |
| SCHEMBL13986981 | 0.87 | GSK3B (0.52) | GSK3BROCK2GAAFLT1KDR | |
| Trifluoroacetic Acid SCHEMBL5658515 | 0.86 | ROCK2 (0.60) | GSK3BROCK2GRK2PRKCACASP1 | |
| SCHEMBL4854602 | 0.86 | GSK3B (0.63) | GSK3BSORT1ROCK2GRK2PRKCA | |
| Trifluoroacetic Acid SCHEMBL5657921 | 0.85 | GSK3B (0.62) | GSK3BSORT1ROCK2GRK2PRKCA | |
| Trifluoroacetic Acid SCHEMBL5659768 | 0.85 | GSK3B (0.64) | GSK3BSORT1ROCK2GRK2PRKCA | |
| Trifluoroacetic Acid SCHEMBL5658704 | 0.85 | GSK3B (0.67) | GSK3BSORT1LMNAROCK2GRK2 | |
| Trifluoroacetic Acid SCHEMBL5656836 | 0.84 | GSK3B (0.56) | GSK3BSORT1LMNAHPGDROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7309701-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-12-18 | — | — | US | disclosed |