Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CXCR2 | P25025 | 7/20 | 0.48 |
| ▸ | CXCR1 | P25024 | 5/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5657939 | 0.91 | CXCR2 (0.53) | SMN1; SMN2NPC1RAB9AMAPTCYP1A2 | |
| SCHEMBL5658496 | 0.87 | LMNA (0.49) | SMN1; SMN2NPC1RAB9AMAPTCYP1A2 | |
| SCHEMBL5659631 | 0.87 | CXCR1 (0.62) | SMN1; SMN2NPC1RAB9AMAPTCXCR2 | |
| SCHEMBL5657929 | 0.85 | CXCR1 (0.51) | SMN1; SMN2NPC1RAB9AMAPTCYP1A2 | |
| SCHEMBL5657757 | 0.84 | ALDH1A1 (0.58) | SMN1; SMN2NPC1RAB9AMAPTCXCR2 | |
| SCHEMBL5660511 | 0.84 | CXCR1 (0.53) | SMN1; SMN2NPC1RAB9AMAPTCYP1A2 | |
| SCHEMBL5660105 | 0.83 | CXCR1 (0.58) | SMN1; SMN2MAPTCXCR2CXCR1ALDH1A1 | |
| SCHEMBL5658940 | 0.83 | LMNA (0.45) | SMN1; SMN2NPC1RAB9AMAPTCXCR2 | |
| SCHEMBL5661145 | 0.82 | LMNA (0.45) | SMN1; SMN2NPC1RAB9AMAPTCYP1A2 | |
| SCHEMBL5658611 | 0.82 | CXCR1 (0.46) | SMN1; SMN2NPC1RAB9AMAPTCXCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7176310-B1 | Pyrimidinecarboxamide derivatives and their use as anti-inflammatory agents | UCB SA (GB) | 2007-02-13 | — | — | US | claimed |
| US-7176310-B1 | Pyrimidinecarboxamide derivatives and their use as anti-inflammatory agents | UCB SA (GB) | 2007-02-13 | — | — | US | disclosed |