Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK2 | P19525 | 3/20 | 0.45 |
| ▸ | GSK3B | P49841 | 2/20 | 0.45 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.43 |
| ▸ | APAF1 | O14727 | 1/20 | 0.42 |
| ▸ | MITF | O75030 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | CASP9 | P55211 | 1/20 | 0.42 |
| ▸ | CASP6 | P55212 | 1/20 | 0.42 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | RAF1 | P04049 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.40 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.40 |
| ▸ | POLA1 | P09884 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4855719 | 0.95 | EIF2AK2 (0.49) | EIF2AK2GSK3BCXCR4FLT3LMNA | |
| SCHEMBL5233270 | 0.83 | EIF2AK2 (0.47) | EIF2AK2CXCR4RAF1BRAFFLT3 | |
| SCHEMBL4857088 | 0.82 | GSK3B (0.53) | GSK3BFLT3POLA1KCNH2 | |
| SCHEMBL4856852 | 0.79 | GSK3B (0.66) | GSK3BFLT3SYK | |
| SCHEMBL4853882 | 0.78 | GSK3B (0.55) | GSK3BLMNASYK | |
| SCHEMBL4848234 | 0.76 | GSK3B (0.56) | GSK3BRAF1BRAFLMNASYK | |
| Trifluoroacetic Acid SCHEMBL5657525 | 0.73 | GSK3B (0.61) | GSK3BLMNA | |
| SCHEMBL4854463 | 0.73 | GSK3B (0.63) | GSK3BL3MBTL1LMNA | |
| SCHEMBL4854304 | 0.73 | GSK3B (0.58) | GSK3BL3MBTL1LMNASYK | |
| SCHEMBL4847379 | 0.72 | GSK3B (0.49) | GSK3BSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7309701-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-12-18 | — | — | US | disclosed |