Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK2 | P19525 | 3/20 | 0.47 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 3/20 | 0.43 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.39 |
| ▸ | RAF1 | P04049 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4855719 | 0.87 | EIF2AK2 (0.49) | EIF2AK2CXCR4FLT3MKNK1BACE1 | |
| SCHEMBL5234145 | 0.83 | DYRK1A (0.44) | LMNASYKBRAFAURKB | |
| Trifluoroacetic Acid SCHEMBL5658623 | 0.83 | EIF2AK2 (0.45) | EIF2AK2CXCR4FLT3MKNK1BACE1 | |
| SCHEMBL5237798 | 0.81 | AKT3 (0.44) | SYKRAF1BRAFAURKB | |
| SCHEMBL4857088 | 0.74 | GSK3B (0.53) | FLT3KDR | |
| SCHEMBL10323187 | 0.73 | EIF2AK2 (0.53) | EIF2AK2CXCR4FLT3MKNK1BACE1 | |
| SCHEMBL5243212 | 0.71 | GSK3B (0.45) | LMNA | |
| SCHEMBL5235357 | 0.71 | GSK3B (0.66) | EIF2AK2FLT3HDAC1SYKKDR | |
| SCHEMBL5234548 | 0.71 | MAPT (0.49) | LMNA | |
| SCHEMBL4856852 | 0.70 | GSK3B (0.66) | FLT3SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1611121-B1 | PYRIDAZINONE DERIVATIVES AS CDK2-INHIBITORS | AVENTIS PHARMA SA (FR) | 2007-08-08 | — | — | EP | claimed |
| EP-1581505-B1 | PYRIDAZINONE DERIVATIVES AS GSK-3BETA INHIBITORS | SANOFI AVENTIS DEUTSCHLAND (DE) | 2007-08-01 | — | — | EP | claimed |