Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 7/20 | 0.60 |
| ▸ | CXCR1 | P25024 | 5/20 | 0.60 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.49 |
| ▸ | MITF | O75030 | 1/20 | 0.49 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.48 |
| ▸ | CDK2 | P24941 | 1/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.48 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.48 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.47 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.47 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5656205 | 0.82 | CXCR2 (0.53) | CXCR2CXCR1P4HTMHDAC3HDAC1 | |
| SCHEMBL5657748 | 0.78 | CXCR2 (0.65) | CXCR2CXCR1P4HTMNPC1RAB9A | |
| SCHEMBL2703268 | 0.76 | POLB (0.61) | HDAC3HDAC1HDAC2HDAC6NPC1 | |
| SCHEMBL5656328 | 0.76 | P4HTM (0.57) | CXCR2CXCR1P4HTMNPC1RAB9A | |
| SCHEMBL5659975 | 0.75 | CXCR2 (0.73) | CXCR2CXCR1P4HTMNPC1RAB9A | |
| SCHEMBL16436048 | 0.74 | PTPN1 (0.61) | CXCR2CXCR1P4HTMHDAC3HDAC1 | |
| SCHEMBL16436052 | 0.74 | KCNQ3 (0.65) | CXCR2P4HTMNPC1RAB9AMITF | |
| SCHEMBL5845348 | 0.73 | CXCR2 (0.89) | CXCR2CXCR1 | |
| SCHEMBL5846781 | 0.73 | CXCR2 (1.00) | CXCR2CXCR1 | |
| SCHEMBL3064046 | 0.72 | P4HTM (0.67) | CXCR2CXCR1P4HTMNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7176310-B1 | Pyrimidinecarboxamide derivatives and their use as anti-inflammatory agents | UCB SA (GB) | 2007-02-13 | — | — | US | claimed |
| US-7176310-B1 | Pyrimidinecarboxamide derivatives and their use as anti-inflammatory agents | UCB SA (GB) | 2007-02-13 | — | — | US | disclosed |