Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 14/20 | 0.53 |
| ▸ | CXCR1 | P25024 | 13/20 | 0.53 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.47 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 0.47 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5658799 | 0.82 | CXCR2 (0.60) | CXCR2CXCR1P4HTMALDH1A1HDAC3 | |
| SCHEMBL5659634 | 0.81 | CXCR1 (0.58) | CXCR2CXCR1CTNNB1TCF7L2P4HTM | |
| SCHEMBL5846063 | 0.76 | CXCR1 (0.79) | CXCR2CXCR1P4HTMALDH1A1 | |
| SCHEMBL9891433 | 0.73 | HDAC8 (0.42) | CTNNB1TCF7L2ALDH1A1HDAC3HDAC1 | |
| SCHEMBL8352922 | 0.72 | L3MBTL1 (0.54) | HDAC6 | |
| SCHEMBL5658349 | 0.70 | CXCR2 (0.73) | CXCR2CXCR1P4HTMALDH1A1 | |
| SCHEMBL7080560 | 0.70 | NAMPT (0.64) | — | |
| SCHEMBL28466017 | 0.70 | MAPT (0.50) | ALDH1A1 | |
| SCHEMBL5660669 | 0.69 | CXCR2 (0.76) | CXCR2CXCR1P4HTM | |
| SCHEMBL5930648 | 0.69 | POLB (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7176310-B1 | Pyrimidinecarboxamide derivatives and their use as anti-inflammatory agents | UCB SA (GB) | 2007-02-13 | — | — | US | disclosed |