Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.53 |
| ▸ | CDK7 | P50613 | 1/20 | 0.52 |
| ▸ | CDK13 | Q14004 | 1/20 | 0.52 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.52 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.47 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.47 |
| ▸ | LIPC | P11150 | 1/20 | 0.45 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.45 |
| ▸ | GRM1 | Q13255 | 5/20 | 0.45 |
| ▸ | GRM5 | P41594 | 4/20 | 0.45 |
| ▸ | WNT3A | P56704 | 1/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | QDPR | P09417 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.42 |
| ▸ | CDK9 | P50750 | 1/20 | 0.42 |
| ▸ | ATR | Q13535 | 1/20 | 0.41 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5660323 | 0.85 | QDPR (0.47) | NAMPTQDPRTSHRLMNA | |
| SCHEMBL5662063 | 0.83 | NAMPT (0.56) | NAMPTCDK7CDK13CDK12SOS1 | |
| SCHEMBL19104448 | 0.83 | NAMPT (0.57) | NAMPTCDK7CDK13CDK12SOS1 | |
| SCHEMBL4767880 | 0.82 | PDK4 (0.52) | NAMPTCDK7CDK13CDK12PDK4 | |
| SCHEMBL14857260 | 0.81 | NAMPT (0.55) | NAMPTCDK7CDK13CDK12SOS1 | |
| SCHEMBL5660055 | 0.81 | PDK4 (0.62) | NAMPTCDK7CDK13CDK12PDK4 | |
| SCHEMBL15178435 | 0.80 | NAMPT (0.54) | NAMPTCDK7CDK13CDK12SOS1 | |
| SCHEMBL8912847 | 0.79 | NAMPT (0.63) | NAMPTCDK7CDK13CDK12PDK4 | |
| SCHEMBL19103538 | 0.79 | NAMPT (0.55) | NAMPTCDK7CDK13CDK12SOS1 | |
| SCHEMBL24669352 | 0.78 | NAMPT (0.53) | NAMPTCDK7CDK13CDK12SOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070043080-A1 | Substituted anilinic piperidines as MCH selective antagonists | MARZABADI MOHAMMAD R | 2007-02-22 | — | — | US | disclosed |
| US-7067534-B1 | Substituted anilinic piperidines as MCH selective antagonists | H. LUNDBECK A/S (DK) | 2006-06-27 | — | — | US | disclosed |
| US-6727264-B1 | MELANIN CONCENTRATING HORMONE-1 RECEPTOR ANTAGONISTS; SLEEP, EATING, SEXUAL DISORDERS | SYNAPTIC PHARMACEUTICAL CORPORATION | 2004-04-27 | — | — | US | disclosed |
| US-20040038855-A1 | DNA encoding a human melanin concentrating hormone receptor (MCH1) and uses thereof | H. LUNDBECK A/S (DK) | 2004-02-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070043080-A1 | Substituted anilinic piperidines as MCH selective antagonists | MCHR1, MCHR2, MC1R | NAMPT 1815/4885CDK7 3981/4885CDK13 4553/4885 |
| US-20040038855-A1 | DNA encoding a human melanin concentrating hormone receptor (MCH1) and uses thereof | MCHR1, MCHR2, MC1R | NAMPT 4179/4885CDK7 3258/4885CDK13 2657/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.