Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BIRC5 | O15392 | 1/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 12/20 | 0.49 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.49 |
| ▸ | CDC7 | O00311 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.47 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5660143 | 0.89 | BIRC5 (0.67) | BIRC5CYP19A1CDC7CDK2ROCK1 | |
| SCHEMBL4295429 | 0.86 | KCNH2 (0.60) | BIRC5KCNH2CYP19A1 | |
| SCHEMBL5660626 | 0.83 | BIRC5 (0.51) | BIRC5KCNH2CYP19A1CDC7CDK2 | |
| SCHEMBL5660019 | 0.83 | BIRC5 (0.54) | BIRC5KCNH2CYP19A1CDC7CDK2 | |
| SCHEMBL157573 | 0.82 | BIRC5 (0.62) | BIRC5CYP19A1CDC7CDK2ROCK1 | |
| SCHEMBL27626324 | 0.79 | BIRC5 (0.50) | BIRC5CYP19A1CDC7CDK2ROCK1 | |
| Urea SCHEMBL4437676 | 0.79 | ROCK2 (0.54) | BIRC5KCNH2 | |
| SCHEMBL5661109 | 0.77 | ROCK2 (0.56) | BIRC5CYP19A1CDC7CDK2ROCK1 | |
| SCHEMBL5659157 | 0.76 | BIRC5 (0.47) | BIRC5CYP19A1CDC7CDK2ROCK1 | |
| SCHEMBL694975 | 0.76 | KCNH2 (0.46) | BIRC5KCNH2CYP19A1CDC7CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070043080-A1 | Substituted anilinic piperidines as MCH selective antagonists | MARZABADI MOHAMMAD R | 2007-02-22 | — | — | US | disclosed |
| US-7067534-B1 | Substituted anilinic piperidines as MCH selective antagonists | H. LUNDBECK A/S (DK) | 2006-06-27 | — | — | US | disclosed |
| CN-1671386-A | Substituted anilinic piperidines as MCH selective antagonists | LUNDBECK & CO AS H (DK) | 2005-09-21 | — | — | CN | disclosed |
| EP-1411942-A4 | SUBSTITUTED ANILINIC PIPERIDINES AS MCH SELECTIVE ANTAGONISTS | SYNAPTIC PHARMA CORP (US) | 2005-01-26 | — | — | EP | disclosed |
| EP-1411942-A1 | SUBSTITUTED ANILINIC PIPERIDINES AS MCH SELECTIVE ANTAGONISTS | Synaptic Pharmaceutical Corporation (US) | 2004-04-28 | — | — | EP | disclosed |
| US-6727264-B1 | MELANIN CONCENTRATING HORMONE-1 RECEPTOR ANTAGONISTS; SLEEP, EATING, SEXUAL DISORDERS | SYNAPTIC PHARMACEUTICAL CORPORATION | 2004-04-27 | — | — | US | disclosed |
| WO-2003004027-A1 | SUBSTITUTED ANILINIC PIPERIDINES AS MCH SELECTIVE ANTAGONISTS | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 2003-01-16 | — | — | WO | disclosed |
| US-5457115-A | Treating anxiety, depression, sleep disorders, migranes, schizophrenia or Parkinson's disease in humans | H. LUNDBECK A/S (DK) | 1995-10-10 | — | — | US | disclosed |
| EP-0465398-B1 | Novel indole derivatives | LUNDBECK & CO AS H (DK) | 1994-12-14 | — | — | EP | disclosed |
| US-5322851-A | Indole derivatives | H. LUNDBECK A/S (DK) | 1994-06-21 | — | — | US | disclosed |
| US-5216001-A | Central nervous system disorders | H. LUNBECK A/S (DK) | 1993-06-01 | — | — | US | disclosed |
| EP-0465398-A2 | Novel indole derivatives | H. LUNDBECK A/S (DK) | 1992-01-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070043080-A1 | Substituted anilinic piperidines as MCH selective antagonists | MCHR1, MCHR2, MC1R | BIRC5 2851/4885KCNH2 2003/4885CYP19A1 487/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.