Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 1/20 | 0.54 |
| ▸ | PIM1 | P11309 | 1/20 | 0.54 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 12/20 | 0.52 |
| ▸ | BIRC5 | O15392 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | MGLL | Q99685 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4295429 | 0.91 | KCNH2 (0.60) | ROCK2PIM1PIM3KCNH2BIRC5 | |
| SCHEMBL7651847 | 0.79 | KCNH2 (0.58) | KCNH2 | |
| SCHEMBL6593806 | 0.79 | AHR (0.54) | KCNH2BIRC5 | |
| SCHEMBL5659440 | 0.79 | BIRC5 (0.54) | KCNH2BIRC5 | |
| SCHEMBL28942962 | 0.77 | KCNH2 (0.49) | ROCK2PIM1PIM3KCNH2EPHX2 | |
| SCHEMBL30365056 | 0.77 | KCNH2 (0.49) | ROCK2PIM1PIM3KCNH2EPHX2 | |
| SCHEMBL121755 | 0.77 | MGLL (0.56) | ROCK2PIM1PIM3KCNH2EPHX2 | |
| SCHEMBL15712902 | 0.76 | MPO (0.49) | ROCK2PIM1PIM3KCNH2EPHX2 | |
| SCHEMBL122499 | 0.75 | KCNH2 (0.57) | ROCK2PIM1PIM3KCNH2EPHX2 | |
| SCHEMBL5735272 | 0.75 | KCNH2 (0.60) | KCNH2BIRC5EPHX2MGLLHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090264656-A1 | METHOD FOR MANUFACTURE OF SERTINDOLE | H. LUNDBECK A/S (DK) | 2009-10-22 | — | — | US | disclosed |
| US-20050101788-A1 | Method for manufacture of sertindole | H. LUNDBECK A/S (DK) | 2005-05-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050101788-A1 | Method for manufacture of sertindole | HTR3C, TPH1, SLC6A4 | ROCK2 4065/4885PIM1 3339/4885PIM3 2934/4885 |
| US-20090264656-A1 | METHOD FOR MANUFACTURE OF SERTINDOLE | HTR3C, TPH1, SLC6A4 | ROCK2 3994/4885PIM1 3214/4885PIM3 2807/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.