Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.71 |
| ▸ | LMNA | P02545 | 2/20 | 0.71 |
| ▸ | MEN1 | O00255 | 1/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.71 |
| ▸ | PIM1 | P11309 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | PARP1 | P09874 | 2/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | DPP4 | P27487 | 1/20 | 0.42 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | GMNN | O75496 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30576393 | 1.00 | KDM4E (0.71) | KDM4ELMNAMEN1KMT2APIM1 | |
| Hydrochloric Acid SCHEMBL27739682 | 0.98 | KDM4E (0.69) | KDM4ELMNAMEN1KMT2APIM1 | |
| SCHEMBL6529041 | 0.85 | KDM4E (0.76) | KDM4ELMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL30505600 | 0.83 | KDM4E (1.00) | KDM4ELMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL30381290 | 0.83 | KDM4E (1.00) | KDM4ELMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL2887500 | 0.83 | KDM4E (0.73) | KDM4ELMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL125654 | 0.83 | KDM4E (1.00) | KDM4ELMNAMEN1KMT2AALDH1A1 | |
| Benzamide SCHEMBL27821964 | 0.82 | KMT2A (0.77) | KDM4ELMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL123373 | 0.81 | KDM4E (0.71) | KDM4ELMNAMEN1KMT2AALDH1A1 | |
| Fluoride SCHEMBL28821496 | 0.81 | KDM4E (0.96) | KDM4ELMNAMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 170 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119751447-A | Asymmetric catalytic synthesis method of naphthyridine formamide medicament | 上海彩迩文生化科技有限公司 | 2025-04-04 | — | — | CN | claimed |
| US-11524966-B1 | Carboxamides as ubiquitin-specific protease inhibitors | VALO HEALTH, INC. (US) | 2022-12-13 | — | — | US | claimed |
| CN-109952302-B | Positive allosteric modulators of muscarinic M1 receptors | 苏文生命科学有限公司 | 2020-11-24 | — | — | CN | claimed |
| WO-2020021300-A1 | USE OF MYELOPEROXIDASE (MPO) INHIBITORS FOR THE TREATMENT OF CHEMORESISTANT ACUTE MYELOID LEUKEMIA (AML) | INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) | 2020-01-30 | — | — | WO | claimed |
| CN-109952302-A | Muscarine M1 receptor forward direction allosteric modulators | 苏文生命科学有限公司 | 2019-06-28 | — | — | CN | claimed |
| EP-2928470-A1 | THIENOPYRIDINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF DENGUE VIRUS INFECTIONS | Siga Technologies, Inc. (US) | 2015-10-14 | — | — | EP | claimed |
| CN-103183676-B | A group of 1-substituted-1, 8-naphthyridine formamide derivatives and preparation and application thereof | INST MED BIOTECHNOLOGY CAMS | 2015-04-08 | — | — | CN | claimed |
| CN-103957910-A | Compounds and methods for enhancing innate immune responses | GLAXOSMITHKLINE LLC | 2014-07-30 | — | — | CN | claimed |
| WO-2014089378-A1 | THIENOPYRIDINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF DENGUE VIRUS INFECTIONS | SIGA TECHNOLOGIES, INC. (US) | 2014-06-12 | — | — | WO | claimed |
| EP-2723717-A2 | TRPM8 ANTAGONISTS AND THEIR USE IN TREATMENTS | Amgen Inc. (US) | 2014-04-30 | — | — | EP | claimed |
| WO-2012177893-A2 | TRPM8 ANTAGONISTS AND THEIR USE IN TREATMENTS | AMGEN INC. (US) | 2012-12-27 | — | — | WO | claimed |
| US-20100291606-A1 | SCREENING SYSTEM FOR DETECTING INHIBITORS OF HIV INTEGRASE-LEDGF/p-75 INTERACTION | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2010-11-18 | — | — | US | claimed |
| US-20090247559-A1 | Benzofuropyrimidinones | EXELIXIS, INC. (US) | 2009-10-01 | — | — | US | claimed |
| US-20060116368-A1 | 4-Piperidinecarboxamide modulators of vanilloid VR1 receptor | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-06-01 | — | — | US | claimed |
| WO-2006058338-A2 | 4 - PIPERIDINECARBOXAMIDE DERIVATIVES AS MODULATORS OF VANILLOID VR1 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-06-01 | — | — | WO | claimed |
| CN-119751447-B | Asymmetric catalytic synthesis method of naphthyridine formamide medicament | 上海彩迩文生化科技有限公司 | 2025-10-14 | — | — | CN | disclosed |
| CN-119751447-B | Asymmetric catalytic synthesis method of naphthyridine formamide medicament | 上海彩迩文生化科技有限公司 | 2025-10-14 | — | — | CN | disclosed |
| US-6143760-A | Substituted 4-oxo-napthyridine-3-carboxamides: GABA brain receptor ligands | NEUROGEN CORPORATION (US) | 2000-11-07 | — | — | US | disclosed |
| EP-1007526-A1 | SUBSTITUTED 4-OXO-NAPTHYRIDINE-3-CARBOXAMIDES AS GABA BRAIN RECEPTOR LIGANDS | NEUROGEN CORPORATION (US) | 2000-06-14 | — | — | EP | disclosed |
| WO-1999010347-A1 | SUBSTITUTED 4-OXO-NAPTHYRIDINE-3-CARBOXAMIDES AS GABA BRAIN RECEPTOR LIGANDS | NEUROGEN CORPORATION (US) | 1999-03-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11524966-B1 | Carboxamides as ubiquitin-specific protease inhibitors | USP28, USP25, USP24 | KDM4E 403/4885LMNA 3132/4885MEN1 3554/4885 |
| US-20090247559-A1 | Benzofuropyrimidinones | F12, BRI3BP, BRD1 | KDM4E 1855/4885LMNA 2545/4885MEN1 1111/4885 |
| US-20060116368-A1 | 4-Piperidinecarboxamide modulators of vanilloid VR1 receptor | VDAC1, TRPV1, HVCN1 | KDM4E 2664/4885LMNA 3237/4885MEN1 4809/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.