Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
| ▸ | NSD2 | O96028 | 1/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.42 |
| ▸ | PRKX | P51817 | 1/20 | 0.42 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.42 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.42 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.42 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 4/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.40 |
| ▸ | PLK4 | O00444 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5663345 | 0.99 | HRH3 (0.48) | HRH3NSD2ROCK1ROCK2AURKA | |
| Hydrochloric Acid SCHEMBL29862494 | 0.82 | NSD2 (0.46) | HRH3NSD2ROCK1ROCK2AURKA | |
| Hydrochloric Acid SCHEMBL29862497 | 0.82 | NSD2 (0.49) | HRH3NSD2ROCK1ROCK2AURKA | |
| Hydrochloric Acid SCHEMBL29862846 | 0.82 | NSD2 (0.46) | HRH3NSD2ROCK1ROCK2AURKA | |
| Hydrochloric Acid SCHEMBL28834082 | 0.82 | NSD2 (0.49) | HRH3NSD2ROCK1ROCK2AURKA | |
| Hydrochloric Acid SCHEMBL23360282 | 0.82 | NSD2 (0.46) | HRH3NSD2ROCK1ROCK2AURKA | |
| Hydrochloric Acid SCHEMBL5662526 | 0.82 | NSD2 (0.46) | HRH3NSD2ROCK1ROCK2AURKA | |
| SCHEMBL12537719 | 0.81 | HRH3 (0.51) | HRH3ROCK1ROCK2MAPK1CDC42BPB | |
| SCHEMBL15169798 | 0.80 | ROCK2 (0.41) | NSD2ROCK1ROCK2TGFBR1 | |
| SCHEMBL15169799 | 0.80 | ROCK2 (0.41) | NSD2ROCK1ROCK2TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7094789-B2 | 5-substituted isoquinoline derivatives | ASAHI KASEI PHARMA CORPORATION (JP) | 2006-08-22 | — | — | US | disclosed |
| EP-1541559-A1 | 5-SUBSTITUTED ISOQUINOLINE DERIVATIVE | Asahi Kasei Pharma Corporation (JP) | 2005-06-15 | — | — | EP | disclosed |
| US-20050020623-A1 | 5-Substituted isoquinoline derivatives | ASAHI KASEI PHARMA CORPORATION (JP) | 2005-01-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050020623-A1 | 5-Substituted isoquinoline derivatives | MYLK, MYLK2, MYL12A | HRH3 1769/4885NSD2 3184/4885ROCK1 75/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.