Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A1 | P22736 | 1/20 | 0.53 |
| ▸ | MAOA | P21397 | 2/20 | 0.51 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | TOP2A | P11388 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL8057298 | 0.98 | NR4A1 (0.51) | NR4A1MAOAMAOBGAAALDH1A1 | |
| SCHEMBL32490152 | 0.98 | NR4A1 (0.54) | NR4A1MAOAMAOBGAAALDH1A1 | |
| SCHEMBL3682351 | 0.98 | NR4A1 (0.54) | NR4A1MAOAMAOBGAAALDH1A1 | |
| SCHEMBL30931819 | 0.98 | NR4A1 (0.54) | NR4A1MAOAMAOBGAAALDH1A1 | |
| SCHEMBL3682352 | 0.98 | NR4A1 (0.54) | NR4A1MAOAMAOBGAAALDH1A1 | |
| SCHEMBL5589850 | 0.97 | NR4A1 (0.53) | NR4A1MAOAMAOBGAAALDH1A1 | |
| SCHEMBL3973168 | 0.91 | NR4A1 (0.47) | NR4A1MAOAMAOBGAAALDH1A1 | |
| SCHEMBL3973166 | 0.91 | NR4A1 (0.47) | NR4A1MAOAMAOBGAAALDH1A1 | |
| SCHEMBL5588926 | 0.90 | NR4A1 (0.49) | NR4A1MAOAMAOBGAAALDH1A1 | |
| SCHEMBL18086818 | 0.90 | NR4A1 (0.49) | NR4A1MAOAMAOBGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1069949-A4 | POLYMERIZATION CATALYSTS AND PROCESSES THEREFOR | CHEVRON PHILLIPS CHEMICAL CO (US) | 2006-05-24 | — | — | EP | disclosed |
| US-6399725-B1 | SLURRY POLYMERIZATION OF ETHYLENE | PHILLIPS PETROLEUM COMPANY | 2002-06-04 | — | — | US | disclosed |
| EP-1069949-A1 | POLYMERIZATION CATALYSTS AND PROCESSES THEREFOR | ConocoPhillips Company (US) | 2001-01-24 | — | — | EP | disclosed |
| US-6150295-A | Polymerization catalysts and processes therefor | PHILLIPS PETROLEUM COMPANY (US) | 2000-11-21 | — | — | US | disclosed |
| WO-1999049969-A1 | POLYMERIZATION CATALYSTS AND PROCESSES THEREFOR | PHILLIPS PETROLEUM COMPANY (US) | 1999-10-07 | — | — | WO | disclosed |