Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5664584 | 0.79 | KDM4E (0.40) | ALDH1A1KDM4ESMN1; SMN2MAPTLMNA | |
| SCHEMBL4989140 | 0.79 | HTT (0.40) | ALDH1A1POLBCYP1A2MAPTTSHR | |
| SCHEMBL5664580 | 0.76 | HDAC3 (0.45) | ALDH1A1KDM4ECYP1A2SMN1; SMN2LMNA | |
| SCHEMBL14152063 | 0.76 | KDM4E (0.41) | ALDH1A1KDM4ECYP1A2SMN1; SMN2MAPT | |
| SCHEMBL5666957 | 0.75 | HDAC3 (0.43) | ALDH1A1KDM4ECYP1A2SMN1; SMN2L3MBTL1 | |
| SCHEMBL5665489 | 0.75 | HDAC3 (0.50) | ALDH1A1KDM4ECYP1A2SMN1; SMN2L3MBTL1 | |
| SCHEMBL5664191 | 0.74 | HDAC3 (0.55) | ALDH1A1KDM4ECYP1A2SMN1; SMN2HPGD | |
| SCHEMBL1516264 | 0.73 | NPC1 (0.45) | ALDH1A1KDM4ECYP1A2SMN1; SMN2LMNA | |
| SCHEMBL5665952 | 0.73 | HDAC6 (0.57) | ALDH1A1CYP1A2SMN1; SMN2CYP2C19HDAC3 | |
| SCHEMBL1515297 | 0.73 | L3MBTL1 (0.54) | ALDH1A1KDM4ESMN1; SMN2MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716137-A1 | SUBSTITUTED QUINOLINE COMPOUNDS | Pfizer Products Incorporated (US) | 2006-11-02 | — | — | EP | disclosed |
| WO-2005080373-A1 | SUBSTITUTED QUINOLINE COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2005-09-01 | — | — | WO | disclosed |