Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | PKM | P14618 | 2/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | FNTA | P49354 | 1/20 | 0.45 |
| ▸ | FNTB | P49356 | 1/20 | 0.45 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.45 |
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2327597 | 0.84 | KEAP1 (0.50) | LMNAPKMKEAP1ALDH1A1GAA | |
| SCHEMBL11610956 | 0.84 | LMNA (0.58) | LMNAPKMRAB9ATSHRSMN1; SMN2 | |
| SCHEMBL5057496 | 0.81 | FOLH1 (0.50) | LMNAPKMKEAP1ALDH1A1MAPT | |
| SCHEMBL3955074 | 0.80 | GAA (0.55) | LMNAPKMKEAP1ALDH1A1GAA | |
| SCHEMBL4740890 | 0.80 | GAA (0.55) | LMNAPKMKEAP1ALDH1A1GAA | |
| Fluoride SCHEMBL28465175 | 0.79 | GAA (0.53) | LMNAPKMKEAP1ALDH1A1GAA | |
| SCHEMBL2327298 | 0.78 | KMT2A (0.60) | LMNAPKMALDH1A1TSHRKMT2A | |
| SCHEMBL2327300 | 0.78 | KMT2A (0.60) | LMNAPKMALDH1A1TSHRKMT2A | |
| SCHEMBL11613363 | 0.77 | NPSR1 (0.58) | LMNAPKMRAB9AMAPTSMN1; SMN2 | |
| SCHEMBL27968741 | 0.75 | MAPT (0.49) | LMNAPKMRAB9AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1443919-A4 | DUAL INHIBITORS OF ADIPOCYTE FATTY ACID BINDING PROTEIN AND KERATINOCYTE FATTY ACID BINDING PROTEIN | BRISTOL MYERS SQUIBB CO (US) | 2006-03-22 | — | — | EP | disclosed |
| EP-1443919-A1 | DUAL INHIBITORS OF ADIPOCYTE FATTY ACID BINDING PROTEIN AND KERATINOCYTE FATTY ACID BINDING PROTEIN | Bristol-Myers Squibb Company (US) | 2004-08-11 | — | — | EP | disclosed |
| WO-2003043624-A1 | DUAL INHIBITORS OF ADIPOCYTE FATTY ACID BINDING PROTEIN AND KERATINOCYTE FATTY ACID BINDING PROTEIN | BRISTOL-MYERS SQUIBB COMPANY (US) | 2003-05-30 | — | — | WO | disclosed |